Peromyscus Laboratory Models for Biomedical Research

用于生物医学研究的 Peromyscus 实验室模型

• 批准号: 7373511
• 负责人: Michael Ray Felder
• 金额: $ 19.38万
• 依托单位: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7373511
• 关键词: American; Area; Attention; Babesiosis; Basic Science; Behavior; Biological Preservation; Biology; Biomedical Research; Bioterrorism; Breeding; Chromosome Mapping; Chromosome Painting; Communicable Diseases; Count; Cryopreservation; Databases; Deer Mouse; Development; Disease; Ehrlichiosis; Embryo Transfer; Emerging Communicable Diseases; Epidemiology; Facility Construction Funding Category; Figs - dietary; Fluorescent in Situ Hybridization; Funding; Genetic; Genomic Imprinting; Genomics; Habitats; Hantavirus; House mice; Human; Hybrids; Internet; Investigation; Laboratories; Laboratory mice; Lyme Disease; Mammals; Modeling; Molecular Cytogenetics; Movement Disorders; Mus; North America; Peromyscus; Phylogenetic Analysis; Physiological; Physiology; Plague; Positioning Attribute; Process; Publications; Range; Rattus; Rattus norvegicus; Research; Research Personnel; Resources; Rest; Rodent; Role; Social Behavior; Source; Study models; Support of Research; Syndrome; Technology; United States; White-Footed Mouse; Xenobiotic Metabolism; base; environmental toxicology; genetic technology; improved; microorganism; mortality; mutant; pathogen; positional cloning; sperm cell

The Peromyscus Genetic Stock Center is a unique facility. The Stock Center is unmatched for its role as a reliable source of disease free peromyscines, and unmatched for the variety of Peromyscus species and mutants available. The Stock Center is utilized by researchers in a wide range of fields, including human infectious disease. Peromyscines came to the Nation's attention in recent years for their role as the primary reservoir of two emerging infectious disease microorganisms. One of these, hantavirus, causes a disease with near 40% mortality, and is on the list of potential bioterrorism agents. The other one is the etiological agent of Lyme disease, a debilitating disease which counts 15,000 new cases annually. Stock Center resources are used extensively by investigators studying these and other diseases such as Ehrlichiosis, babesiosis and plague. Other research areas benefiting from Stock Center resources include the mechanism and cure of repetitive movement disorders, the genetics of disrupted genomic imprinting, the physiological basis of social behavior, and environmental toxicology. To continue supporting these research endeavors the Stock Center proposes: 1) to continue providing peromyscines for biomedical and related research, 2) to promote the species and its advantages, and 3) to improve the usefulness of Peromyscus as a laboratory model. Funds are requested to enable development of the sperm cryopreservation technology to provide a more economical means of storing some of the rare mutants maintained by the Stock Center. Funds are also requested to support the construction of a Peromyscus genomics database, and to use fluorescence in situ hybridization to globally determine regions of homology between Mus and Peromyscus, thereby expediting development of a linkage map.

Peromyscus遗传资源中心是一个独特的设施。股票交易中心的作用是无与伦比的