Peromyscus Laboratory Models for Biomedical Research

Peromyscus遗传储备中心是一个独特的设施。股票中心是无与伦比的作用， 无病害peromyscines的可靠来源，对于多种Peromyscus物种和 变种人可用股票中心是利用研究人员在广泛的领域，包括人类 传染病Peromyscines近年来引起了国家的注意，因为它们作为 两种新出现的传染病微生物的主要储存者。其中之一，汉坦病毒， 这种疾病的死亡率接近40%，并被列入潜在的生物恐怖主义制剂名单。另一个是 莱姆病的病原体，这是一种使人衰弱的疾病，每年有15，000例新病例。股票 中心资源被研究这些疾病和其他疾病的研究人员广泛使用， 埃立克体病，巴贝虫病和鼠疫。从股票中心资源中受益的其他研究领域包括 重复性运动障碍的机制和治疗，基因组印记破坏的遗传学， 社会行为的生理学基础和环境毒理学。继续支持这些研究 努力股票中心建议：1）继续提供peromyscines为生物医学和相关 研究，2）促进物种及其优势，3）提高Peromyscus作为 实验室模型。 要求提供资金，以便开发精子冷冻保存技术， 这是一种经济的方式来储存一些由库存中心保存的稀有突变体。基金也是 要求支持建立一个Peromyscus基因组学数据库，并使用荧光原位 杂交以全面地确定小鼠和鹿鼠之间的同源性区域，从而加速 绘制一张连锁图。

The Peromyscus Genetic Stock Center is a unique facility. The Stock Center is unmatched for its role as a reliable source of disease free peromyscines, and unmatched for the variety of Peromyscus species and mutants available. The Stock Center is utilized by researchers in a wide range of fields, including human infectious disease. Peromyscines came to the Nation's attention in recent years for their role as the primary reservoir of two emerging infectious disease microorganisms. One of these, hantavirus, causes a disease with near 40% mortality, and is on the list of potential bioterrorism agents. The other one is the etiological agent of Lyme disease, a debilitating disease which counts 15,000 new cases annually. Stock Center resources are used extensively by investigators studying these and other diseases such as Ehrlichiosis, babesiosis and plague. Other research areas benefiting from Stock Center resources include the mechanism and cure of repetitive movement disorders, the genetics of disrupted genomic imprinting, the physiological basis of social behavior, and environmental toxicology. To continue supporting these research endeavors the Stock Center proposes: 1) to continue providing peromyscines for biomedical and related research, 2) to promote the species and its advantages, and 3) to improve the usefulness of Peromyscus as a laboratory model. Funds are requested to enable development of the sperm cryopreservation technology to provide a more economical means of storing some of the rare mutants maintained by the Stock Center. Funds are also requested to support the construction of a Peromyscus genomics database, and to use fluorescence in situ hybridization to globally determine regions of homology between Mus and Peromyscus, thereby expediting development of a linkage map.