Peromyscus Laboratory Models for Biomedical Research

Permyscus基因储备中心是一个独特的设施。股票中心是无与伦比的 无病假单胞菌的可靠来源，以及无与伦比的假单胞菌种类和种类 有变种人可用。股票中心被广泛的领域的研究人员利用，包括人类 传染病。近年来，Permyscines因其扮演的角色而受到国家的关注 两种新出现的传染病微生物的主要蓄水池。其中一种，汉坦病毒，会导致 这种疾病有近40%的死亡率，并被列入潜在的生物恐怖主义因子名单。另一个是 莱姆病是一种使人衰弱的疾病，每年新增病例15,000例。库存 研究这些疾病和其他疾病的研究人员广泛使用中心资源，例如 埃立克体病、巴贝斯虫病和鼠疫。受益于股票中心资源的其他研究领域包括 重复运动障碍的机制和治疗，基因组印迹中断的遗传学， 社会行为的生理基础和环境毒理学。继续支持这些研究 努力股票中心建议：1)继续为生物医学及相关领域提供霉菌类药物 研究，2)推广该物种及其优势，3)提高Permyscus作为 实验室模型。 需要资金以使精子冷冻保存技术的开发能够提供更多的 储存一些由库存中心维护的稀有突变体的经济手段。基金也在 请求支持建立一个Permyscus基因组学数据库，并使用原位荧光 杂交以全局确定小鼠和Permyscus之间的同源区域，从而加快 连锁图的开发。

The Peromyscus Genetic Stock Center is a unique facility. The Stock Center is unmatched for its role as a reliable source of disease free peromyscines, and unmatched for the variety of Peromyscus species and mutants available. The Stock Center is utilized by researchers in a wide range of fields, including human infectious disease. Peromyscines came to the Nation's attention in recent years for their role as the primary reservoir of two emerging infectious disease microorganisms. One of these, hantavirus, causes a disease with near 40% mortality, and is on the list of potential bioterrorism agents. The other one is the etiological agent of Lyme disease, a debilitating disease which counts 15,000 new cases annually. Stock Center resources are used extensively by investigators studying these and other diseases such as Ehrlichiosis, babesiosis and plague. Other research areas benefiting from Stock Center resources include the mechanism and cure of repetitive movement disorders, the genetics of disrupted genomic imprinting, the physiological basis of social behavior, and environmental toxicology. To continue supporting these research endeavors the Stock Center proposes: 1) to continue providing peromyscines for biomedical and related research, 2) to promote the species and its advantages, and 3) to improve the usefulness of Peromyscus as a laboratory model. Funds are requested to enable development of the sperm cryopreservation technology to provide a more economical means of storing some of the rare mutants maintained by the Stock Center. Funds are also requested to support the construction of a Peromyscus genomics database, and to use fluorescence in situ hybridization to globally determine regions of homology between Mus and Peromyscus, thereby expediting development of a linkage map.