RESTORATION OF INTEGRIN FUNCTION IN CHRONIC MYELOGIC LEUKEMIA (CML)

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to understand why leukemia cells grow in an unregulated manner compared with normal marrow cells and how the biological agent interferon restores normal growth characteristics of leukemia cells. Marrow forming cells from patients with leukemia do not respond appropriately to signals capable of regulating the growth of marrow forming cells from normal individuals. Certain sticky proteins on the surface of normal marrow cells called integrins, which are important for regulation of growth, function abnormally in leukemia cells but their function can be restored to normal by interferon. In this study we will try to discover why these proteins function abnormally in leukemia cells compared with normal cells, and how interferon corrects this abnormality. Results from these studies may help us to design improved treatments for leukemia.