Fundamentals, Development and Applications of Ion Mobility Spectrometry (IMS) for Enhanced Trace Detection of Threat Agents

用于增强威胁代理痕量检测的离子淌度光谱 (IMS) 的基础知识、开发和应用

• 批准号: EP/E027571/1
• 负责人: Chris Mayhew
• 金额: $ 66.88万
• 依托单位: University of Birmingham
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2007
• 资助国家: 英国
• 起止时间: 2007 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FE027571%2F1
• 关键词: Fundamentals; Development; Applications; Ion; Mobility

The globalisation of our society means that there is an ever-increasing need, within homeland security, for reliable, real-time and sensitive detection of a wide range of substances that are a threat to our society. The chemicals to be detected range from explosives, through to illicit narcotics and chemical and biological agents. The ability to quickly and accurately measure these hazardous compounds, and distinguish them from a complex chemical environment, is vital to our nation's needs for its fight against crime and terrorism.Commonly used equipments for this type of security are often based on Ion Mobility Spectrometry (IMS), and which are often employed to screen people or objects. You may have experienced its application at airports if you had your laptop checked for traces of explosives, or if you walked through a Sentinel , used to screen people for trace amounts of explosives or narcotics. IMS is however, not only employed in transportation security, but also in military and civilian facilities.IMS operates by creating charged molecules (ions), which can either be positively or negatively charged. These ions migrate under the influence of an electric field with a mean constant velocity and collide with neutral molecules. Collisions and reactions (ion-molecule reactions) lead to the formation of other ionic species which may react with a trace gas. Changes in the resultant mobility of ions as they progress along an electric field are monitored and processed to try to identify any threat materials present.The IMS systems currently deployed have a number of limitations, including sensitivity and selectivity, which result in the technology not being fully exploited. The major limitation is low chemical specificity, restricting the type of compounds which can be readily detected. Many explosives and chemical threats just can not be detected. To overcome this requires a novel scientific approach, employing a detailed fundamental and phased research programme to understand the key chemical processes employed in IMS, and in particular to those occuring in the latest generation of drift tube systems being developed by Smiths Detection Ltd, Watford, UK. A systematic study is required which will investigate the ionization chemistry, the use of chemical dopants (to change the chemistry), and mode of operation (negative or positive ion mode, high or low electric field). An Ion Trap Mass Spectrometer (ITMS), coupled to novel IMS systems, will be the main device employed to study the complex ion chemistry. One of the advantages of the ITMS is that structural information on the ions can be obtained. By utilizing and tailoring the ion chemistry it will be possible to refine, extend, and enhance the operation of IMS. Together with lead scientists and engineers working in the world's largest company which manufactures, develops and markets IMS systems, the UK based company Smiths Detection Ltd (website address: www.smithsdetection.com and http://trace.smithsdetection.com/), we will pursue a four year programme of research to achieve the above objectives. Through Smiths Detection Ltd, this should lead to the development of a unique instrument, increasing the dimensionality of current IMS systems, ultimately leading to a new generation of chemical detectors to be deployed to fight crime and terrorism and increase security within the UK.

我们社会的全球化意味着，在国土安全领域，对威胁我们社会的各种物质进行可靠、实时和灵敏的检测的需求日益增加。需要检测的化学品包括爆炸物、非法麻醉品以及化学和生物制剂。快速准确地测量这些有害化合物，并将其与复杂的化学环境区分开来，对于我们国家打击犯罪和恐怖主义的需求至关重要。用于这类安全的常用设备通常基于离子迁移谱仪（IMS），通常用于筛查人员或物体。如果您检查笔记本电脑是否有爆炸物的痕迹，或者如果您走过用于筛选微量爆炸物或毒品的哨兵，您可能已经在机场体验过它的应用。然而，IMS不仅用于运输安全，还用于军事和民用设施。IMS通过产生带电分子（离子）来工作，这些分子可以带正电或带负电。这些离子在电场的影响下以平均恒定速度迁移，并与中性分子碰撞。碰撞和反应（离子-分子反应）导致形成可能与痕量气体反应的其他离子物质。当离子沿着电场前进时，离子的最终迁移率的变化被监测和处理，以试图识别存在的任何威胁材料。目前部署的国际监测系统有一些局限性，包括敏感性和选择性，这导致该技术没有得到充分利用。主要的限制是化学特异性低，限制了可以容易检测的化合物的类型。许多爆炸物和化学威胁无法被检测到。为了克服这一点，需要一种新的科学方法，采用详细的基础和分阶段的研究计划，以了解在IMS中采用的关键化学过程，特别是那些发生在最新一代的漂移管系统正在开发的史密斯检测有限公司，沃特福德，英国。需要进行系统的研究，以调查电离化学，化学掺杂剂的使用（以改变化学）和操作模式（负或正离子模式，高或低电场）。离子阱质谱仪（ITMS），耦合到新的IMS系统，将是主要的设备，用于研究复杂的离子化学。ITMS的优点之一是可以获得离子的结构信息。通过利用和定制离子化学，将有可能改进、扩展和增强IMS的操作。我们将与世界上最大的制造、开发和销售国际监测系统的公司-英国史密斯探测有限公司（网址：www.smithsdetection.com和http：//trace.smithsdetection.com/）的主要科学家和工程师一道，开展一项为期四年的研究方案，以实现上述目标。通过史密斯探测有限公司，这将导致开发一种独特的仪器，增加当前IMS系统的维度，最终导致部署新一代化学探测器，以打击犯罪和恐怖主义，并提高英国的安全性。

项目成果

The kinetics and product state distributions from gas-phase reactions of small atomic and molecular cations with C2H4, C2H3F, 1,1-C2H2F2, C2HF3 and C2F4.

小原子和分子阳离子与 C2H4、C2H3F、1,1-C2H2F2、C2HF3 和 C2F4 的气相反应的动力学和产物状态分布。

• DOI: 10.1039/c3cp54881c
• 发表时间: 2014
• 期刊: PCCP
• 作者: Parkes MA

Technical Advances in Proton Transfer Reaction-Mass Spectrometry and New Fields of Application

质子转移反应-质谱技术进展及新应用领域

• 期刊: American Laboratory
• 作者: Philipp Sulzer (Author)