Interdisciplinary Training in Signals Controlling Ingestion and Obesity

控制摄入和肥胖信号的跨学科培训

• 批准号: 7435733
• 负责人: RICHARD D MATTES
• 金额: $ 4.41万
• 依托单位: PURDUE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7435733
• 关键词: Ingestion; Obesity; Signal Transduction; Training

DESCRIPTION (provided by applicant): Obesity is a complex, costly public health problem with increasing incidence and prevalence. To more comprehensively address the factors that cause and perpetuate the problem and to prevent the associated diseases will require the perspectives and integrative approaches of researchers receiving multidisciplinary training While overweight/obesity stem from positive energy balance (i.e., intake>expenditure), our view is that the predominant problem is feeding dysregulation attributable to errors in regulatory signaling. To further understanding in this area, the present proposal seeks funds to train doctoral students to conduct collaborative research in the area of feeding dysregulation and obesity. This will be accomplished primarily through the Ingestive Behavior Research Center (IBRC) on the Purdue University Campus which is comprised of faculty heading established laboratories with state-of-the-art resources with expertise in the areas of nutrition, physiology, sensory science, endocrinology, metabolism, genetics, food science, psychology and nursing. Didactic training consists of a core curriculum that covers nutritional biochemistry and physiology, statistical methods and research design, controls of feeding and ethics. This is supplemented with more specific and advanced courses in neural systems, endocrinology, sensory systems, infant and child feeding, aging and food science to meet the individual training interests and needs of each trainee. Additional specialized training opportunities are available through researchers associated with the Purdue program in public health, the Purdue Cancer Center, the Purdue Agricultural Research Service and the Indiana University School of Medicine, A distinguished lecturer series and biannual international symposium bring experts to the Center from outside the University to seed new ideas. Students are required to attend and present seminars as well. Thus, research training is provided that can support projects ranging from molecular biology to clinical trials. Satisfactory completion of the IBRC curriculum will be recognized by six departments as an Area of Specialization and so noted on their official transcript. Entering students must have a bachelor's degree in a science field. It is expected they will complete their doctoral training in 4-5 years. Funds are requested for two new students per year who will be supported for two years (a total of 4 trainees). Additional support for completion of the degree program will be provided by a combination of grants awarded to the trainers, a NIH program project grant, USDA training grant, Purdue University fellowships and departmental funds. A better understanding of the factors that guide food choice, eating patterns and portion size should yield insights for the development of more effective therapeutic interventions and weight management recommendations. Didactic and research training on feeding regulation through the IBRC will provide trainees with the knowledge and skill sets necessary to build that understanding.

描述（由申请人提供）： 肥胖是一个复杂，昂贵的公共卫生问题，发病率和流行率增加。要更全面地解决引起问题和永久性疾病并预防相关疾病的因素，将需要接受多学科培训的研究人员的观点和整合方法，而超重/肥胖源于正能量平衡（即摄入>摄入>花费），我们的观点是，主要的问题是，主要的问题是源代码归因于归属于误差的信号，以征集信号性。为了进一步了解这一领域，本提案寻求资金来培训博士生，以在喂养失调和肥胖领域进行合作研究。这将主要通过普渡大学校园的Ingestive行为研究中心（IBRC）实现，该中心由领导既定实验室的教师，具有最先进的资源，具有最先进的资源，在营养，生理学，感觉科学，内分泌学，内分泌学，代谢，遗传学，食品科学，心理学和护理方面具有专业知识。教学培训由一个核心课程组成，该课程涵盖营养生物化学和生理学，统计方法和研究设计，喂养和道德的控制。这补充了神经系统，内分泌系统，感官系统，婴儿和儿童喂养，衰老和食品科学的更具体，更先进的课程，以满足每个学员的个人培训兴趣和需求。通过与普渡大学公共卫生计划，普渡大学癌症中心，普渡大学农业研究服务和印第安纳大学医学院，杰出的讲师系列和一年一度的国际研讨会相关的研究人员提供其他专业培训机会。学生也必须参加并举办研讨会。因此，提供了可以支持从分子生物学到临床试验的项目。 IBRC课程的令人满意的完成将被六个部门认可为一个专业领域，因此在其正式笔录中指出。进入学生必须拥有科学领域的学士学位。预计他们将在4 - 5年内完成博士培训。每年要求两名新学生提供资金，他们将获得两年的支持（共4名学员）。将通过授予培训师，NIH计划项目赠款，USDA培训补助金，普渡大学奖学金和部门资金的赠款组合提供了为完成学位课程的额外支持。更好地理解指导食物选择，饮食方式和份量大小的因素，应为开发更有效的治疗干预措施和体重管理建议提供见解。关于通过IBRC喂养法规的教学和研究培训将为受训者提供建立这种理解所需的知识和技能。