Interdisciplinary Training in Signals Controlling Ingestion and Obesity

描述(由申请人提供)： 肥胖是一个复杂、代价高昂的公共卫生问题，发病率和流行率都在不断上升。为了更全面地解决导致和延续这一问题的因素，并预防相关疾病，将需要接受多学科培训的研究人员的视角和综合方法，而超重/肥胖源于正能量平衡(即摄入量和支出)。我们的观点是，主要问题是可归因于监管信号错误的喂养失调。为了进一步了解这一领域，本提案寻求资金来培训博士生，以便在喂养失调和肥胖领域开展合作研究。这将主要通过普渡大学校区的消化行为研究中心(IBRC)实现，该中心由领导现有实验室的教职员工组成，拥有最先进的资源，拥有营养、生理学、感官科学、内分泌学、新陈代谢、遗传学、食品科学、心理学和护理领域的专业知识。教学培训包括一门核心课程，涵盖营养生物化学和生理学、统计方法和研究设计、喂养控制和伦理。此外，还有神经系统、内分泌学、感官系统、婴儿和儿童喂养、老龄化和食品科学等更具体和更高级的课程，以满足每个学员的个人培训兴趣和需求。通过与普渡大学公共卫生项目、普渡大学癌症中心、普渡农业研究服务中心和印第安纳大学医学院相关的研究人员提供更多的专业培训机会，一个杰出的讲师系列和一年两次的国际研讨会将来自大学以外的专家聚集到该中心来传播新的想法。学生还被要求参加并介绍研讨会。因此，提供的研究培训可以支持从分子生物学到临床试验的各种项目。令人满意地完成IBRC课程将被六个部门认可为专业领域，并在其正式成绩单上注明。入学的学生必须拥有理科领域的学士学位。预计他们将在4-5年内完成博士培训。每年为两名新生申请资金，他们将得到两年的资助(共4名受训人员)。完成学位课程的额外支持将由授予培训者的补助金、NIH计划项目补助金、美国农业部培训补助金、普渡大学奖学金和部门基金提供。更好地了解指导食物选择、饮食模式和分量大小的因素，应该有助于开发更有效的治疗干预措施和体重管理建议。通过IBRC进行的关于喂养规则的教学和研究培训将为受训者提供必要的知识和技能，以建立这种理解。

DESCRIPTION (provided by applicant): Obesity is a complex, costly public health problem with increasing incidence and prevalence. To more comprehensively address the factors that cause and perpetuate the problem and to prevent the associated diseases will require the perspectives and integrative approaches of researchers receiving multidisciplinary training While overweight/obesity stem from positive energy balance (i.e., intake>expenditure), our view is that the predominant problem is feeding dysregulation attributable to errors in regulatory signaling. To further understanding in this area, the present proposal seeks funds to train doctoral students to conduct collaborative research in the area of feeding dysregulation and obesity. This will be accomplished primarily through the Ingestive Behavior Research Center (IBRC) on the Purdue University Campus which is comprised of faculty heading established laboratories with state-of-the-art resources with expertise in the areas of nutrition, physiology, sensory science, endocrinology, metabolism, genetics, food science, psychology and nursing. Didactic training consists of a core curriculum that covers nutritional biochemistry and physiology, statistical methods and research design, controls of feeding and ethics. This is supplemented with more specific and advanced courses in neural systems, endocrinology, sensory systems, infant and child feeding, aging and food science to meet the individual training interests and needs of each trainee. Additional specialized training opportunities are available through researchers associated with the Purdue program in public health, the Purdue Cancer Center, the Purdue Agricultural Research Service and the Indiana University School of Medicine, A distinguished lecturer series and biannual international symposium bring experts to the Center from outside the University to seed new ideas. Students are required to attend and present seminars as well. Thus, research training is provided that can support projects ranging from molecular biology to clinical trials. Satisfactory completion of the IBRC curriculum will be recognized by six departments as an Area of Specialization and so noted on their official transcript. Entering students must have a bachelor's degree in a science field. It is expected they will complete their doctoral training in 4-5 years. Funds are requested for two new students per year who will be supported for two years (a total of 4 trainees). Additional support for completion of the degree program will be provided by a combination of grants awarded to the trainers, a NIH program project grant, USDA training grant, Purdue University fellowships and departmental funds. A better understanding of the factors that guide food choice, eating patterns and portion size should yield insights for the development of more effective therapeutic interventions and weight management recommendations. Didactic and research training on feeding regulation through the IBRC will provide trainees with the knowledge and skill sets necessary to build that understanding.