Interdisciplinary Training in Signals Controlling Ingestion and Obesity

描述（由申请人提供）： 肥胖症是一个复杂的，昂贵的公共卫生问题，发病率和流行率不断增加。为了更全面地解决导致和延续问题的因素并预防相关疾病，将需要接受多学科培训的研究人员的观点和综合方法。摄入>支出），我们的观点是，主要问题是可归因于调控信号错误的摄食失调。为了进一步了解这一领域，本提案寻求资金，以培训博士生在喂养失调和肥胖领域进行合作研究。这将主要通过普渡大学校园内的摄食行为研究中心（IBRC）来完成，该中心由拥有营养学，生理学，感官科学，内分泌学，新陈代谢，遗传学，食品科学，心理学和护理领域专业知识的最先进资源的教师领导的实验室组成。教学培训包括一个核心课程，涵盖营养生物化学和生理学、统计方法和研究设计、喂养控制和道德。这是补充神经系统，内分泌学，感觉系统，婴幼儿喂养，老龄化和食品科学更具体和先进的课程，以满足每个学员的个人培训兴趣和需求。与普渡大学公共卫生项目、普渡大学癌症中心、普渡大学农业研究服务中心和印第安纳州医学院相关的研究人员还提供额外的专业培训机会，杰出讲师系列和一年两次的国际研讨会将专家从大学外带到该中心，为新想法提供种子。学生也必须参加并出席研讨会。因此，提供研究培训，可以支持从分子生物学到临床试验的项目。IBRC课程的圆满完成将被六个部门认可为专业领域，并在其正式成绩单上注明。入学学生必须拥有科学领域的学士学位。预计他们将在4-5年内完成博士课程。每年申请资助两名新生，为期两年（共4名受训人员）。完成学位课程的额外支持将由授予培训师的赠款、NIH项目赠款、美国农业部培训赠款、普渡大学奖学金和部门资金提供。更好地了解指导食物选择，饮食模式和份量的因素应该为制定更有效的治疗干预措施和体重管理建议提供见解。通过IBRC进行的关于喂养调节的教学和研究培训将为学员提供建立这种理解所需的知识和技能。

DESCRIPTION (provided by applicant): Obesity is a complex, costly public health problem with increasing incidence and prevalence. To more comprehensively address the factors that cause and perpetuate the problem and to prevent the associated diseases will require the perspectives and integrative approaches of researchers receiving multidisciplinary training While overweight/obesity stem from positive energy balance (i.e., intake>expenditure), our view is that the predominant problem is feeding dysregulation attributable to errors in regulatory signaling. To further understanding in this area, the present proposal seeks funds to train doctoral students to conduct collaborative research in the area of feeding dysregulation and obesity. This will be accomplished primarily through the Ingestive Behavior Research Center (IBRC) on the Purdue University Campus which is comprised of faculty heading established laboratories with state-of-the-art resources with expertise in the areas of nutrition, physiology, sensory science, endocrinology, metabolism, genetics, food science, psychology and nursing. Didactic training consists of a core curriculum that covers nutritional biochemistry and physiology, statistical methods and research design, controls of feeding and ethics. This is supplemented with more specific and advanced courses in neural systems, endocrinology, sensory systems, infant and child feeding, aging and food science to meet the individual training interests and needs of each trainee. Additional specialized training opportunities are available through researchers associated with the Purdue program in public health, the Purdue Cancer Center, the Purdue Agricultural Research Service and the Indiana University School of Medicine, A distinguished lecturer series and biannual international symposium bring experts to the Center from outside the University to seed new ideas. Students are required to attend and present seminars as well. Thus, research training is provided that can support projects ranging from molecular biology to clinical trials. Satisfactory completion of the IBRC curriculum will be recognized by six departments as an Area of Specialization and so noted on their official transcript. Entering students must have a bachelor's degree in a science field. It is expected they will complete their doctoral training in 4-5 years. Funds are requested for two new students per year who will be supported for two years (a total of 4 trainees). Additional support for completion of the degree program will be provided by a combination of grants awarded to the trainers, a NIH program project grant, USDA training grant, Purdue University fellowships and departmental funds. A better understanding of the factors that guide food choice, eating patterns and portion size should yield insights for the development of more effective therapeutic interventions and weight management recommendations. Didactic and research training on feeding regulation through the IBRC will provide trainees with the knowledge and skill sets necessary to build that understanding.