Interdisciplinary Training in Signals Controlling Ingestion and Obesity

控制摄入和肥胖信号的跨学科培训

• 批准号: 8667145
• 负责人: RICHARD D MATTES
• 金额: $ 7.32万
• 依托单位: PURDUE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2019-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8667145
• 关键词: Ingestion; Obesity; Signal Transduction; Training

DESCRIPTION (provided by applicant): There is little controversy that overweight and obesity are prevalent and pose myriad health, work and economic challenges for individuals and the population. While energy expenditure and physical activity, specifically, are integral components of energy balance and a healthy lifestyle, the dominant driver of weight gain is energy consumption. There are strong data documenting parallel trends for BMI, portion size and eating frequency. It is our view that these associations reflect dysfunctional feeding stemming from insensitivity or errors of signaling systems that underlie ingestive behavior. This grant seeks funds to train predoctoral students for the study of healthful and dysfunctional feeding to address the problem of obesity. Training will be highly interdisciplinary and coordinated through the Ingestive Behavior Research Center (IBRC) at Purdue University. The Center is comprised of approximately 56 faculty residing in twelve departments on the West Lafayette campus as well as researchers at the Indiana University School of Medicine (IUSM). They bring expertise in the areas of nutrition, food science, psychology, animal science, neurology, physiology, genetics, endocrinology, sensory science, anthropology and agricultural economics. The Center curriculum includes didactic training in biochemistry, physiology, controls of feeding in humans and animal models, research design, statistics and ethics. This is augmented by advanced specialty courses in the areas of sensory studies, infant and child feeding, aging, food science, neural systems and health policy. Students are also encouraged to take advantage of other available resources on campus such as courses, activities and research opportunities offered through the Public Health Program, Cancer Center, Agricultural Research Center and Women's Global Health Institute to name only a few. IBRC also hosts a biennial international conference on topics related to ingestive behavior that requires participation by trainees and supports a visiting scholars program and special topics course, both of which bring eminent researchers to campus to interact with the trainees. Funds from the prior training grant supported two trainees per year and, based on our experience, success and growing demand, we now request support for two trainees per year over the next five years (5 total trainees). Complementary support for trainees will be provided by funds from various federal agencies, the University, and private donations to the trainers. Providing predoctoral students training on the antecedents, consequences and management of dysfunction eating and the skills necessary to further understanding of related issues should hasten resolution of the overweight/obesity problem.

描述(申请人提供)：几乎没有争议，超重和肥胖是普遍存在的，并给个人和人口带来无数的健康、工作和经济挑战。虽然能量消耗和体力活动是能量平衡和健康生活方式不可或缺的组成部分，但体重增加的主要驱动因素是能量消耗。有强有力的数据记录了体重指数、份量和进食频率的平行趋势。我们认为，这些联系反映了进食功能障碍，源于作为摄食行为基础的信号系统的不敏感或错误。这笔资金用于培训博士前学生，研究健康和功能失调的喂养，以解决肥胖问题。培训将是高度跨学科的，并通过普渡大学的消化行为研究中心(IBRC)进行协调。该中心由西拉斐特校区12个系的约56名教职员工以及印第安纳大学医学院(IUSM)的研究人员组成。他们带来了营养、食品科学、心理学、动物科学、神经学、生理学、遗传学、内分泌学、感官科学、人类学和农业经济学等领域的专业知识。该中心的课程包括生物化学、生理学、人类和动物模型的喂养控制、研究设计、统计学和伦理学方面的教学培训。在感官研究、婴儿和儿童喂养、老龄化、食品科学、神经系统和卫生政策等领域的高级专业课程加强了这一点。还鼓励学生利用校园内的其他可用资源，如通过公共卫生计划、癌症中心、农业研究中心和妇女全球健康研究所提供的课程、活动和研究机会，仅举几例。IBRC还举办了两年一次的国际会议，讨论与进食行为相关的主题，需要学员参与，并支持访问学者项目和专题课程，这两个项目都将著名的研究人员带到校园与学员互动。以前的培训补助金每年资助两名受训人员，根据我们的经验、成功和不断增长的需求，我们现在请求在今后五年内每年支助两名受训人员(共5名受训人员)。对受训者的补充支持将由各联邦机构、大学提供的资金以及对培训者的私人捐款提供。为博士生提供关于进食障碍的前兆、后果和管理的培训，以及进一步了解相关问题所需的技能，应该会加速解决超重/肥胖问题。