Interdisciplinary Training in Signals Controlling Ingestion and Obesity

描述（由申请人提供）：超重和肥胖普遍存在，给个人和人群带来了无数的健康、工作和经济挑战，这一点几乎没有争议。虽然能量消耗和身体活动是能量平衡和健康生活方式的组成部分，但体重增加的主要驱动因素是能量消耗。有强有力的数据表明，身体质量指数、食物份量和进食频率呈平行趋势。我们的观点是，这些关联反映了摄食行为背后的信号系统的不敏感或错误所导致的功能失调。这项拨款旨在培养博士预科生，研究健康和功能失调的喂养方式，以解决肥胖问题。培训将是高度跨学科的，并通过普渡大学的摄食行为研究中心（IBRC）进行协调。该中心由居住在西拉斐特校区12个部门的大约56名教师以及印第安纳大学医学院（usm）的研究人员组成。他们带来了营养学、食品科学、心理学、动物科学、神经学、生理学、遗传学、内分泌学、感官科学、人类学和农业经济学等领域的专业知识。该中心的课程包括生物化学、生理学、人类和动物模型喂养控制、研究设计、统计学和伦理学等方面的教学培训。感官研究、婴幼儿喂养、老龄化、食品科学、神经系统和卫生政策等领域的高级专业课程加强了这一点。学校还鼓励学生利用校园内的其他资源，如公共卫生项目、癌症中心、农业研究中心和妇女全球健康研究所提供的课程、活动和研究机会。IBRC还举办两年一次的国际会议，讨论与进食行为有关的主题，需要学员参加，并支持访问学者计划和专题课程，这两个项目都邀请了杰出的研究人员到校园与学员互动。以前的培训补助金每年支持两名学员，根据我们的经验、成功和不断增长的需求，我们现在要求在未来五年每年支持两名学员（总共5名学员）。对受训者的补充支助将由各联邦机构、大学和对培训人员的私人捐款提供。为博士生提供有关饮食失调的前因、后果和管理的培训，以及进一步了解相关问题所需的技能，应加快超重/肥胖问题的解决。

DESCRIPTION (provided by applicant): There is little controversy that overweight and obesity are prevalent and pose myriad health, work and economic challenges for individuals and the population. While energy expenditure and physical activity, specifically, are integral components of energy balance and a healthy lifestyle, the dominant driver of weight gain is energy consumption. There are strong data documenting parallel trends for BMI, portion size and eating frequency. It is our view that these associations reflect dysfunctional feeding stemming from insensitivity or errors of signaling systems that underlie ingestive behavior. This grant seeks funds to train predoctoral students for the study of healthful and dysfunctional feeding to address the problem of obesity. Training will be highly interdisciplinary and coordinated through the Ingestive Behavior Research Center (IBRC) at Purdue University. The Center is comprised of approximately 56 faculty residing in twelve departments on the West Lafayette campus as well as researchers at the Indiana University School of Medicine (IUSM). They bring expertise in the areas of nutrition, food science, psychology, animal science, neurology, physiology, genetics, endocrinology, sensory science, anthropology and agricultural economics. The Center curriculum includes didactic training in biochemistry, physiology, controls of feeding in humans and animal models, research design, statistics and ethics. This is augmented by advanced specialty courses in the areas of sensory studies, infant and child feeding, aging, food science, neural systems and health policy. Students are also encouraged to take advantage of other available resources on campus such as courses, activities and research opportunities offered through the Public Health Program, Cancer Center, Agricultural Research Center and Women's Global Health Institute to name only a few. IBRC also hosts a biennial international conference on topics related to ingestive behavior that requires participation by trainees and supports a visiting scholars program and special topics course, both of which bring eminent researchers to campus to interact with the trainees. Funds from the prior training grant supported two trainees per year and, based on our experience, success and growing demand, we now request support for two trainees per year over the next five years (5 total trainees). Complementary support for trainees will be provided by funds from various federal agencies, the University, and private donations to the trainers. Providing predoctoral students training on the antecedents, consequences and management of dysfunction eating and the skills necessary to further understanding of related issues should hasten resolution of the overweight/obesity problem.