NRSA Institutional Training Program in Oral Biology

描述（由申请人提供）：为响应NIDCR的机构培训计划的呼吁，培养能够应对牙科，口腔和颅面研究中的机遇和挑战的熟练和多才多艺的科学家，提出了一项全面的T32 NRSA口腔生物学机构培训补助金。该提案是佛罗里达大学口腔生物学T32培训补助金的延续。这个广泛的口腔生物学基础和临床生物医学研究培训计划将有助于满足对基础的、多学科的口腔生物医学研究的持续需求，并弥补临床医生/科学家和转化的、面向患者的口腔和颅面研究人员的严重短缺。资金充足的基础和临床研究人员聚集在一起，提供与口腔健康问题有关的生物医学科学方面的各种培训机会。研究培训的重点将是口腔细菌和真菌传染病、宿主寄生虫相互作用、疫苗策略、相关自身免疫性疾病、结缔组织生物学、基因治疗和牙科/颅面临床研究。本提案的具体目标是：1)培养从事口腔健康问题研究的基础多学科生物医学科学家；2)培养以病人为本的牙科临床医师；3)培养具有博士学位的临床科学家和牙科专业人才；4)开展临床调查培训，培养牙科临床和翻译研究人员；5)为牙科学生和牙科教师提供临床调查和基础牙科和颅面研究的短期经验，以促进他们成为临床科学家的兴趣和成功。将利用牙科学院和医学院的跨学科研究训练计划。研究培训资源包括生物医学跨学科博士项目、临床研究高级专业项目、普通临床研究中心和资金充足的基础和临床生物医学科学家。通过结合这些资源和其他资源，提供了一个综合和灵活的培训计划，将满足各种受训人员的需要，并最大限度地培养“高技能和互动的科学家骨干”，他们能够成功地设计和测试新知识，以推进口腔和颅面结构疾病和异常的检测、治疗、预防和治愈。的相关性。口腔疾病是人类中传播最广泛的疾病之一。它们会导致严重的身体和心理不适，经济困难，并对一个人的整体健康产生负面影响。需要继续进行研究，以发现、治疗和预防口腔疾病，以改善人类的福祉。这项训练奖助金将培养基础和临床科学家，他们将开发和实施改善全球口腔健康的新方法。

DESCRIPTION (provided by applicant): In response to the NIDCR's call for institutional training programs to produce skilled and versatile scientists who can address the opportunities and challenges in dental, oral and craniofacial research a Comprehensive T32 NRSA Institutional Training Grant in Oral Biology is proposed. The proposal is a continuation of a T32 Training Grant in Oral Biology at the University of Florida. This broad based training program in basic and clinical biomedical investigations in oral biology will help to satisfy the continuing need for basic, multidisciplinary biomedical oral health research and to remedy the serious shortage of clinician/scientist and translational, patient oriented oral and craniofacial researchers. A combination of well funded, basic and clinical researchers have been brought together to provide a variety of training opportunities in biomedical sciences relevant to issues in oral health. The focus of the research training will be in oral bacterial and mycotic infectious diseases, host parasite interactions, vaccine strategies, relevant autoimmune diseases, connective tissue biology, gene therapy, and dental/craniofacial clinical research. The specific aims of this proposal are: 1) to produce basic multidisciplinary biomedical scientists to do research on issues of oral health; 2) to produce patient oriented dental clinician scientists; 3) to produce clinician scientists with a PhD and dental specialty training; 4) to provide clinical investigation training to produce dental clinical and translation researchers; and 5) to provide short-term experiences for dental students and dental faculty in clinical investigation and basic dental and craniofacial research to promote their interest and success in careers as clinician scientists. Interdisciplinary research training programs in the Colleges of Dentistry and Medicine will be utilized. Research training resources include the PhD Interdisciplinary Program in Biomedical Sciences, an Advanced Professional Program in Clinical Investigation, the General Clinical Research Center and well funded basic and clinical biomedical scientists. By using combinations of these and other resources, an integrated and flexible training program is offered that will meet the needs of a variety of trainees and have maximum potential to produce a "cadre of highly skilled and interactive scientists" who can successfully devise and test new knowledge to advance the detection, treatment, prevention and cure of diseases and abnormalities of the oral and craniofacial structures. Relevance. Oral diseases are some of the most wide spread diseases in the human population. They can result in severe physical and psychological discomfort, financial hardship, and negatively affect a person's general health. Continued research is needed to detect, treat and prevent oral diseases to improve the well being of the human population. This training grant will produce basic and clinical scientists who will develop and implement new methods to improve oral health World-wide.