Coordinating and Bioinformatics Unit for the AMDCC/MMPC

描述(由申请人提供)： 糖尿病并发症动物模型协会(AMDCC)和小鼠代谢表型中心(MMPC)是由美国国立卫生研究院资助的两个多中心倡议。在当前的五年筹资周期中，AMDCC主要负责开发和表征模仿人类糖尿病并发症的动物模型。AMDCC由8个动物工程中心、3个表型核心和1个协调和生物信息学单位(CBU)组成，由来自14个不同机构的研究人员组成。对该财团的监督来自NIH和一个外部咨询委员会(EAC)。我的实验室是AMDCC目前的CBU，负责组织该联盟的活动，包括管理责任以及开发储存、传播和分析AMDCC产生的数据所需的信息基础设施。相比之下，MMPC负责为科学界提供标准化的、高质量的小鼠代谢和生理表型服务。MMPC向研究人员收费提供最先进的技术，他们的服务包括表征老鼠的新陈代谢、血液成分(包括激素)、能量平衡、饮食和运动、器官功能和形态、生理学和组织学。按照官方说法，这两个财团在各自的使命方面没有互动或协调活动。作为更新这两个财团的一部分，国家卫生研究院决定整合和协调它们的活动。为了促进这一互动，一个CBU将负责建立和维护必要的行政、科学和信息学基础设施，以组织和便利其业务。这项提议的目标是提供这种基础设施。我们将在当前AMDCC CBU基础设施的成功基础上，为AMDCC和MMPC提供强大和全面的面向服务的解决方案，支持每个实体的共同和独特方面。具体地说，我们将：1)为行政和协调活动提供支持；2)创建和维护必要的信息学基础设施，以支持两个财团的活动。

DESCRIPTION (provided by applicant): The Animal Models of Diabetic Complications Consortium (AMDCC) and the Mouse Metabolic Phenotyping Centers (MMPC) are two multi-center initiatives funded by the NIH. During the current five year funding cycle, the AMDCC had the primary responsibility of developing and characterizing animal models that mimic human diabetic complications. The AMDCC consists of 8 animal engineering centers, 3 phenotyping cores and 1 coordinating and bioinformatics unit (CBU) with investigators from 14 separate institutions. Oversight of the consortium comes from both the NIH and an External Advisory Committee (EAC). My laboratory is the current CBU for the AMDCC and is responsible for organizing the activities of the consortium, including the administrative responsibilities as well as the development of the informatics infrastructure required to store, disseminate and analyze the data generated by the AMDCC. In contrast, the MMPCs were charged with providing the scientific community with standardized, high quality metabolic and physiologic phenotyping services for the mouse. The MMPC provides state-of-the-art technologies to investigators for a fee, with their services including characterization of mouse metabolism, blood composition (including hormones), energy balance, eating and exercise, organ function and morphology, physiology and histology. Officially, these two consortia had no interaction or coordination of activities with regard to their respective missions. As part of the renewal of these two consortia, the NIH has decided to integrate and coordinate their activities. In order to facilitate this interaction, one CBU will be responsible for creating and maintaining the administrative, scientific and informatics infrastructure necessary to organize and facilitate their operations. The goal of this proposal is to provide that infrastructure. We will build upon the success of the current AMDCC CBU infrastructure to provide both the AMDCC and MMPC with a robust and comprehensive service oriented solution that supports both the common and unique aspects of each entity. Specifically, we will: 1) Provide Support for the Administrative and Coordinating Activities; and 2) Create and Maintain the Informatics Infrastructure Necessary to Support the Activities of both Consortia.