Coordinating and Bioinformatics Unit for the AMDCC/MMPC

糖尿病并发症动物模型及小鼠代谢表型的研究 中心(MMPC)是由美国国立卫生研究院资助的两个多中心倡议。在目前的五年资助期间 循环期间，AMDCC的主要责任是开发和表征模仿 人类糖尿病并发症。AMDCC由8个动物工程中心，3个表型核心组成 以及1个协调和生物信息学股(CBU)，由来自14个不同机构的调查人员组成。监督 该财团的成员来自美国国立卫生研究院和一个外部咨询委员会(EAC)。我的实验室是 该联盟的现任CBU负责组织该联盟的活动，包括 行政责任以及发展所需的信息学基础设施 存储、传播和分析AMDCC生成的数据。相比之下，MMPC则被充电 为科学界提供标准化、高质量的代谢和生理 鼠标的表型服务。MMPC为调查人员提供最先进的技术 费用，他们的服务包括表征小鼠的新陈代谢，血液成分(包括 激素)、能量平衡、饮食和运动、器官功能和形态、生理学和组织学。 按照官方说法，这两个财团没有就其各自的 任务。作为这两个财团更新的一部分，NIH已决定整合和协调 他们的活动。为了促进这种互动，将由一个CBU负责创建和维护 必要的行政、科学和信息学基础设施，以组织和促进其 行动。这项提议的目标是提供这种基础设施。我们将在成功的基础上继续 当前的AMDCC CBU基础设施为AMDCC和MMPC提供强大的 全面的面向服务的解决方案，既支持每个实体的共同方面，也支持其独特方面。 具体地说，我们将：1)为行政和协调活动提供支持；2)创建和 维护必要的信息学基础设施，以支持两个财团的活动。

The Animal Models of Diabetic Complications Consortium (AMDCC) and the Mouse Metabolic Phenotyping Centers (MMPC) are two multi-center initiatives funded by the NIH. During the current five year funding cycle, the AMDCC had the primary responsibility of developing and characterizing animal models that mimic human diabetic complications. The AMDCC consists of 8 animal engineering centers, 3 phenotyping cores and 1 coordinating and bioinformatics unit (CBU) with investigators from 14 separate institutions. Oversight of the consortium comes from both the NIH and an External Advisory Committee (EAC). My laboratory is the current CBU for the AMDCC and is responsible for organizing the activities of the consortium, including the administrative responsibilities as well as the development of the informatics infrastructure required to store, disseminate and analyze the data generated by the AMDCC. In contrast, the MMPCs were charged with providing the scientific community with standardized, high quality metabolic and physiologic phenotyping services for the mouse. The MMPC provides state-of-the-art technologies to investigators for a fee, with their services including characterization of mouse metabolism, blood composition (including hormones), energy balance, eating and exercise, organ function and morphology, physiology and histology. Officially, these two consortia had no interaction or coordination of activities with regard to their respective missions. As part of the renewal of these two consortia, the NIH has decided to integrate and coordinate their activities. In order to facilitate this interaction, one CBU will be responsible for creating and maintaining the administrative, scientific and informatics infrastructure necessary to organize and facilitate their operations. The goal of this proposal is to provide that infrastructure. We will build upon the success of the current AMDCC CBU infrastructure to provide both the AMDCC and MMPC with a robust and comprehensive service oriented solution that supports both the common and unique aspects of each entity. Specifically, we will: 1) Provide Support for the Administrative and Coordinating Activities; and 2) Create and Maintain the Informatics Infrastructure Necessary to Support the Activities of both Consortia.