Coordinating and Bioinformatics Unit for the AMDCC/MMPC

AMDCC/MMPC 协调和生物信息学单位

• 批准号: 7930256
• 负责人: Richard A. MCINDOE
• 金额: $ 181.97万
• 依托单位: AUGUSTA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7930256
• 关键词: Advisory Committees; Agreement; Animal Model; Animals; Arts; Award; Bioinformatics; Blood; Businesses; Charge; Communication; Communities; Complications of Diabetes Mellitus; Computer Hardware; Computer software; Data; Data Analyses; Development; Eating; Educational workshop; Engineering; Exercise; Feedback; Fees; Funding; General Population; Generations; Goals; Histology; Hormones; Human; Imagery; Informatics; Institution; Laboratories; Maintenance; Metabolic; Metabolism; Mission; Modeling; Morphology; Mus; Online Systems; Operative Surgical Procedures; Organ; Phenotype; Physiological; Physiology; Principal Investigator; Process; Protocols documentation; Records; Reporting; Research Infrastructure; Research Personnel; Services; Solutions; System; Technology; Teleconferences; Training; Travel; United States National Institutes of Health; Universities; data modeling; design; energy balance; meetings; member; programs; software systems; success; symposium; tool

DESCRIPTION (provided by applicant): The Animal Models of Diabetic Complications Consortium (AMDCC) and the Mouse Metabolic Phenotyping Centers (MMPC) are two multi-center initiatives funded by the NIH. During the current five year funding cycle, the AMDCC had the primary responsibility of developing and characterizing animal models that mimic human diabetic complications. The AMDCC consists of 8 animal engineering centers, 3 phenotyping cores and 1 coordinating and bioinformatics unit (CBU) with investigators from 14 separate institutions. Oversight of the consortium comes from both the NIH and an External Advisory Committee (EAC). My laboratory is the current CBU for the AMDCC and is responsible for organizing the activities of the consortium, including the administrative responsibilities as well as the development of the informatics infrastructure required to store, disseminate and analyze the data generated by the AMDCC. In contrast, the MMPCs were charged with providing the scientific community with standardized, high quality metabolic and physiologic phenotyping services for the mouse. The MMPC provides state-of-the-art technologies to investigators for a fee, with their services including characterization of mouse metabolism, blood composition (including hormones), energy balance, eating and exercise, organ function and morphology, physiology and histology. Officially, these two consortia had no interaction or coordination of activities with regard to their respective missions. As part of the renewal of these two consortia, the NIH has decided to integrate and coordinate their activities. In order to facilitate this interaction, one CBU will be responsible for creating and maintaining the administrative, scientific and informatics infrastructure necessary to organize and facilitate their operations. The goal of this proposal is to provide that infrastructure. We will build upon the success of the current AMDCC CBU infrastructure to provide both the AMDCC and MMPC with a robust and comprehensive service oriented solution that supports both the common and unique aspects of each entity. Specifically, we will: 1) Provide Support for the Administrative and Coordinating Activities; and 2) Create and Maintain the Informatics Infrastructure Necessary to Support the Activities of both Consortia.

描述（由申请人提供）： 糖尿病并发症动物模型联盟（AMDCC）和小鼠代谢表型中心（MMPC）是由NIH资助的两个多中心计划。在目前的五年资助周期内，AMDCC主要负责开发和表征模拟人类糖尿病并发症的动物模型。AMDCC由8个动物工程中心，3个表型核心和1个协调和生物信息学单位（CBU）组成，研究人员来自14个独立的机构。该联盟的监督来自NIH和外部咨询委员会（EAC）。我的实验室是AMDCC目前的CBU，负责组织联盟的活动，包括行政职责以及开发存储、传播和分析AMDCC生成的数据所需的信息学基础设施。相比之下，MMPC负责为科学界提供小鼠的标准化，高质量的代谢和生理表型分析服务。MMPC向研究者提供最先进的技术，并收取费用，其服务包括小鼠代谢、血液成分（包括激素）、能量平衡、饮食和运动、器官功能和形态、生理学和组织学的表征。这两个集团在各自的任务方面没有正式的互动或协调活动。作为这两个联盟更新的一部分，NIH决定整合和协调它们的活动。为了促进这种互动，将由一个能力建设股负责建立和维持组织和促进其运作所需的行政、科学和信息学基础设施。本提案的目标是提供这种基础设施。我们将在当前AMDCC CBU基础设施成功的基础上，为AMDCC和MMPC提供一个强大而全面的面向服务的解决方案，支持每个实体的共同和独特方面。具体而言，我们将：1）为管理和协调活动提供支持; 2）创建和维护必要的信息基础设施，以支持两个财团的活动。