Coordinating and Bioinformatics Unit for the AMDCC/MMPC

糖尿病并发症联盟（AMDCC）动物模型及小鼠代谢表型研究 中心（MMPC）是由NIH资助的两个多中心计划。在目前的五年融资中， AMDCC的主要职责是开发和表征模拟 人类糖尿病并发症AMDCC由8个动物工程中心，3个表型中心组成， 和1个协调和生物信息学单位（CBU），由来自14个不同机构的研究人员组成。监督 该联盟的成员来自NIH和外部咨询委员会（EAC）。我的实验室是 目前AMDCC的CBU，负责组织联合体的活动，包括 行政责任以及发展所需的信息基础设施， 存储、传播和分析AMDCC生成的数据。相比之下，MMPC被充电 为科学界提供标准化的，高质量的代谢和生理 为小鼠提供表型分析服务。MMPC为调查人员提供最先进的技术， 费用，他们的服务包括小鼠代谢，血液成分（包括 激素）、能量平衡、饮食和运动、器官功能和形态、生理学和组织学。 正式而言，这两个集团在各自的业务活动方面没有互动或协调。 任务。作为这两个联盟更新的一部分，NIH决定整合和协调 他们的活动。为了促进这种互动，一个CBU将负责创建和维护 为组织和促进这些活动所必需的行政、科学和信息学基础设施， 运营本提案的目标是提供这种基础设施。我们将继续努力， 目前的AMDCC CBU基础设施，为AMDCC和MMPC提供一个强大的， 全面的面向服务的解决方案，支持每个实体的共同和独特方面。 具体而言，我们将：1）为行政和协调活动提供支持; 2）创建和 维护必要的信息基础设施，以支持两个财团的活动。

The Animal Models of Diabetic Complications Consortium (AMDCC) and the Mouse Metabolic Phenotyping Centers (MMPC) are two multi-center initiatives funded by the NIH. During the current five year funding cycle, the AMDCC had the primary responsibility of developing and characterizing animal models that mimic human diabetic complications. The AMDCC consists of 8 animal engineering centers, 3 phenotyping cores and 1 coordinating and bioinformatics unit (CBU) with investigators from 14 separate institutions. Oversight of the consortium comes from both the NIH and an External Advisory Committee (EAC). My laboratory is the current CBU for the AMDCC and is responsible for organizing the activities of the consortium, including the administrative responsibilities as well as the development of the informatics infrastructure required to store, disseminate and analyze the data generated by the AMDCC. In contrast, the MMPCs were charged with providing the scientific community with standardized, high quality metabolic and physiologic phenotyping services for the mouse. The MMPC provides state-of-the-art technologies to investigators for a fee, with their services including characterization of mouse metabolism, blood composition (including hormones), energy balance, eating and exercise, organ function and morphology, physiology and histology. Officially, these two consortia had no interaction or coordination of activities with regard to their respective missions. As part of the renewal of these two consortia, the NIH has decided to integrate and coordinate their activities. In order to facilitate this interaction, one CBU will be responsible for creating and maintaining the administrative, scientific and informatics infrastructure necessary to organize and facilitate their operations. The goal of this proposal is to provide that infrastructure. We will build upon the success of the current AMDCC CBU infrastructure to provide both the AMDCC and MMPC with a robust and comprehensive service oriented solution that supports both the common and unique aspects of each entity. Specifically, we will: 1) Provide Support for the Administrative and Coordinating Activities; and 2) Create and Maintain the Informatics Infrastructure Necessary to Support the Activities of both Consortia.