Coordinating and Bioinformatics Unit for the MMPC/DiaComp

在过去的15年里，我们的小组成功地管理了协调和生物信息学单位（CBU）， 两个NIDDK资助的财团，糖尿病并发症财团（DiaComp 2001年至今，前身为 糖尿病并发症动物模型协会）和小鼠代谢表型中心（MMPC， 2006年至今）。DiaComp提供了一个环境，以促进 参与糖尿病并发症研究的研究者社区。为了实现这一目标，DiaComp赞助 在与复杂问题有关的科学领域举行年度会议，在影响大的领域征求和资助试点项目 糖尿病并发症的研究，并支持一个网站，为糖尿病并发症社区服务。期间 在目前的五年资助周期中，CBU负责通过使用 机会池（供资），管理/维护网站和表型数据， 组织由DiaComp赞助的会议和研讨会， 复杂性科学界。相比之下，MMPC负责提供科学 为小鼠提供标准化、高质量的代谢和生理表型分析服务。的 MMPC为研究者提供最先进的收费技术，其服务包括 小鼠代谢、血液组成（包括激素）、能量平衡、进食和代谢的表征 运动、器官功能和形态学、生理学和组织学。在过去的十年里，两个财团 由于NIH决定整合两个联盟的活动， 第二个融资周期。我们的实验室一直是DiaComp（过去15年）和 MMPC（过去10年）。CBU负责创建和维护行政、科学和 以及组织和促进其运作所需的信息学基础设施。这项提案的目的是 来提供这些基础设施。我们将在当前DiaComp/MMPC CBU成功的基础上再接再厉 为DiaComp和MMPC提供强大而全面的面向服务的解决方案的基础设施 支持每个方面的共同点和独特点。

Over the last 15 years, our group has successfully managed the coordinating and bioinformatics unit (CBU) for two NIDDK funded consortia, the Diabetic Complications Consortium (DiaComp 2001-present, formerly the Animal Models of Diabetic Complications Consortium) and the Mouse Metabolic Phenotyping Centers (MMPC, 2006-present). DiaComp provides an environment to foster communications and collaborations between investigator communities involved in diabetic complications research. Toward this goal, DiaComp sponsors annual meetings in complications-relevant scientific areas, solicits and funds pilot projects in high impact areas of complications research, and supports a website to serve the diabetic complications community. During the current five year funding cycle, the CBU was responsible for continuing support for DiaComp through the use of opportunity pools (funding), manage/maintain the website and phenotyping data and administratively organize the meetings and workshops sponsored by the DiaComp to engage the greater diabetic complications scientific community. In contrast, the MMPCs are charged with providing the scientific community with standardized, high quality metabolic and physiologic phenotyping services for the mouse. The MMPC provides state-of-the-art technologies to investigators for a fee, with their services including characterization of mouse metabolism, blood composition (including hormones), energy balance, eating and exercise, organ function and morphology, physiology and histology. Over the last ten years the two consortia have been managed by one CBU because of the NIH decision to integrate the activities of the two consortia during their second funding cycles. Our laboratory has been the CBU for both DiaComp (last 15 years) and the MMPC (last 10 years). The CBU is responsible for creating and maintaining the administrative, scientific and informatics infrastructure necessary to organize and facilitate their operations. The goal of this proposal is to provide that infrastructure. We will build upon the success of the current DiaComp/MMPC CBU infrastructure to provide both DiaComp and MMPC with a robust and comprehensive service oriented solution that supports both the common and unique aspects of each.