Coordinating and Bioinformatics Unit for the DCC/MMPC

描述（由申请人提供）：糖尿病并发症动物模型联盟（AMDCC）和小鼠代谢表型中心（MMPC）是由NIH资助的两个多中心计划。在目前的五年资助周期内，AMDCC主要负责开发和表征模拟人类糖尿病并发症的动物模型。AMDCC的使命不仅是创建这些模型，而且还向科学界提供这些模型、与其特征有关的数据以及用于生成和分析这些模型的协议。该联盟的监督来自NIH和外部咨询委员会（EAB）。在第三个资助周期，AMDCC将更名为糖尿病并发症联盟（DCC），并将负责通过使用机会池（资助）继续支持DCC动物模型表型，管理/维护网站和表型数据，并在行政上组织由DCC赞助的会议和研讨会，以吸引更多的糖尿病并发症科学界。相比之下，MMPC负责为科学界提供小鼠的标准化，高质量的代谢和生理表型分析服务。MMPC向研究者提供最先进的技术，并收取费用，其服务包括小鼠代谢、血液成分（包括激素）、能量平衡、饮食和运动、器官功能和形态、生理学和组织学的表征。在过去的四年里，这两个联盟一直由一个CBU管理，因为NIH决定在第二个资助周期内整合这两个联盟的活动。我们的实验室一直是AMDCC（过去9年）和MMPC（过去4年）的CBU。CBU负责创建和维护组织和促进其业务所需的行政，科学和信息学基础设施。本提案的目标是提供这种基础设施。我们将在当前AMDCC/MMPC CBU基础设施成功的基础上，为DCC和MMPC提供一个强大而全面的面向服务的解决方案，支持两者的共同点和独特点。

DESCRIPTION (provided by applicant): The Animal Models of Diabetic Complications Consortium (AMDCC) and the Mouse Metabolic Phenotyping Centers (MMPC) are two multi-center initiatives funded by the NIH. During the current five year funding cycle, the AMDCC had the primary responsibility of developing and characterizing animal models that mimic human diabetic complications. The mission of the AMDCC was to not only create these models, but also provide these models, the data relevant to their characterization and the protocols used for their generation and analysis to the scientific community. Oversight of the consortium comes from both the NIH and an External Advisory Board (EAB). During this third funding cycle, the AMDCC will be rebranded as the Diabetic Complications Consortium (DCC) and will be responsible for continuing support for the DCC animal model phenotyping through the use of opportunity pools (funding), manage/maintain the website and phenotyping data and administratively organize the meetings and workshops sponsored by the DCC to engage the greater diabetic complications scientific community. In contrast, the MMPCs are charged with providing the scientific community with standardized, high quality metabolic and physiologic phenotyping services for the mouse. The MMPC provides state-of-the-art technologies to investigators for a fee, with their services including characterization of mouse metabolism, blood composition (including hormones), energy balance, eating and exercise, organ function and morphology, physiology and histology. Over the last four years the two consortia have been managed by one CBU because of the NIH decision to integrate the activities of the two consortia during their second funding cycles. Our laboratory has been the CBU for both the AMDCC (last 9 years) and the MMPC (last 4 years). The CBU is responsible for creating and maintaining the administrative, scientific and informatics infrastructure necessary to organize and facilitate their operations. The goal of this proposal is to provide that infrastructure. We will build upon the success of the current AMDCC/MMPC CBU infrastructure to provide both the DCC and MMPC with a robust and comprehensive service oriented solution that supports both the common and unique aspects of each.