ADOLESCENT MEDICINE TRIALS UNIT

描述（由申请人提供）：纽约州布朗克斯阿尔伯特·爱因斯坦医学院Montefiore医学中心的青少年艾滋病计划（AAP）正在重新竞争成为青少年药物试验单位，以实施艾滋病毒/艾滋病干预青少年药物试验网络（ATN）的临床和行为研究。自1987年以来，AAP的使命一直是为感染艾滋病毒和有感染风险的青少年提供全面的护理和预防服务。美国儿科学会相信，它在提供最高质量的临床护理和研究方面的经验和领导地位，加上社区外展的创新战略，将为NIH在RFA中提出的研究议程提供重要的科学和业务贡献。青少年艾滋病方案参与ATN的具体目标是：1。通过参与协议小组，撰写/审查协议和研究论文，以及传播主要研究成果，为推进ATN的科学议程作出贡献。2. 通过参加电话会议、会议和委员会，为网络的有效运作作出贡献。3. 为青少年提供全面的临床和心理健康服务，以促进他们的临床护理和参加试验，同时确保他们作为研究志愿者的权利和安全。4. 通过招募和保留13至24岁的艾滋病毒阳性和高危青少年参加所有相关的ATN试验，推进艾滋病毒预防和护理。5.通过社区动员和通过“连接到保护”以及其他创新的外联和预防战略进行结构变革，为预防艾滋病毒作出贡献。该方案的目标包括针对感染艾滋病毒和处于危险中的青年开展和实施行为试验、社区转化试验、预防试验、治疗试验和疫苗试验。这些干预研究的成功将有助于对感染艾滋病毒的青年进行更好的临床和行为管理，并对预防青年进一步感染艾滋病毒作出重大贡献。通过其研究和临床经验，以及居住在纽约布朗克斯的艾滋病毒阳性和高危青年人口，AAP处于独特的地位，可以实现这些目标。2004年，AAP照顾了101名艾滋病毒阳性青年（其中60%是女性，98%是少数民族/种族）。布朗克斯居民和青年面临着沉重的艾滋病毒负担，需要继续研究，以制定更有效的预防、病例发现和护理方法。作为贫困率最高的行政区，布朗克斯130万居民的健康状况继续落后于纽约市的其他居民。布朗克斯区的艾滋病患者比美国45个州都多。这项研究将有助于美国儿科学会解决布朗克斯的艾滋病毒/艾滋病公共卫生问题。

DESCRIPTION (provided by applicant): The Adolescent AIDS Program (AAP) at Montefiore Medical Center, Albert Einstein College of Medicine, the Bronx, NY is re-competing to be an Adolescent Medicine Trials Unit to implement clinical and behavioral studies in the Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN). Since 1987, the mission of the AAP has been to provide comprehensive care and prevention services to adolescents living with and at-risk for HIV infection. The AAP believes that its experience and leadership in providing the highest quality clinical care and research, combined with innovative strategies for community outreach will offer important scientific and operational contributions to the research agenda posed in the RFA by the NIH. The Specific Aims of the Adolescent AIDS Program's participation in the ATN are: 1. To contribute to the advancement of the scientific agenda of the ATN through participation in protocol teams, writing/reviewing protocols and research papers and dissemination of key findings. 2. To contribute to the effective operations of the ATN via participation in calls, meetings and committees. 3. To provide a comprehensive array of clinical and mental health services to youth to facilitate their clinical care and enrollment into trials while ensuring their rights and safety as research volunteers. 4. To advance HIV prevention and care by recruiting and retaining HIV positive and at-risk adolescents ages 13 through 24 years into all relevant ATN trials. 5.To contribute to the prevention of HIV via community mobilization and structural change via Connect to Protect (r) and other innovative outreach and prevention strategies. The goals of the RFA include the development and implementation of behavioral, community-based translational, prophylactic, therapeutic and vaccine trials with HIV-infected and at risk youth. The success of these intervention studies will facilitate better clinical and behavioral management for HIV infected youth as well as make a significant contribution to the prevention of further HIV infection among youth. The AAP is uniquely positioned to meet these goals both through its research and clinical experience as well as its population of HIV positive and at-risk youth who reside in the Bronx, New York. In 2004, the AAP cared for101 HIV+ youth (60% of whom are females and 98% of whom are ethnic/racial minorities). The heavy burden of HIV faced by Bronx residents and youth necessitates continued research to develop more effective approaches to prevention, case finding and care. As the borough with the highest rates of poverty, the health status of the 1.3 million Bronx residents continues to lag behind other residents of New York City. The Bronx has more people living with HIV/AIDS than 45 states. This research will help the AAP to address the public health issue of HIV/AIDS in the Bronx.