ADOLESCENT MEDICINE TRIALS UNIT

描述（由申请人提供）：纽约州布朗克斯区爱因斯坦医学院Montefiore医学中心的青少年艾滋病项目（AAP）正在重新竞争成为青少年药物试验单位，以实施艾滋病毒/艾滋病干预青少年药物试验网络（ATN）的临床和行为研究。AAP相信，凭借其在提供最高质量临床护理和研究方面的23年经验和领导地位，加上社区外展的创新战略，将为ATN提供重要的科学和业务贡献。AAP参与ATN的具体目标是：1)通过参与协议小组，撰写/审查协议和研究论文以及传播关键发现，为推进ATN的科学议程做出贡献；2)通过招募和保留13-24岁的艾滋病毒阳性和高危青年参与所有相关的ATN试验，促进艾滋病毒的预防和护理；3)为青少年提供全面的临床和心理健康服务，以促进他们的临床护理和参加试验，同时确保他们作为研究志愿者的权利和安全；4)通过“连接到保护”创新的外展预防策略、社区动员和结构变革，如“布朗克斯知道”，为预防艾滋病毒做出贡献；5)通过参与电话、会议和委员会，为ATN的有效运作做出贡献。该方案的目标包括制定和实施针对艾滋病毒阳性和高危青年的行为、社区和转化、预防、治疗和疫苗试验。这些干预研究的成功将有助于对感染艾滋病毒的青年进行更好的临床和行为管理，并对预防青年感染艾滋病毒作出重大贡献。AAP在实现这些目标方面具有独特的优势，既可以通过经验，也可以通过居住在纽约州布朗克斯的艾滋病毒阳性和高危青年人口来实现。2009年，AAP照顾了134名艾滋病毒阳性患者，其中62%为男性，98%为少数民族/种族。布朗克斯居民和年轻人所面临的沉重的艾滋病毒负担需要继续进行研究。作为全国最贫穷的国会选区，布朗克斯130万居民的健康状况继续落后于纽约市的其他居民。参加该网络将有助于AAP继续在纽约州布朗克斯处理艾滋病毒/艾滋病的公共卫生问题。

DESCRIPTION (provided by applicant): The Adolescent AIDS Program (AAP) at Montefiore Medical Center, Einstein College of Medicine, in the Bronx, NY is re-competing to be an Adolescent Medicine Trials Unit to implement clinical and behavioral Studies in the Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN). The AAP believes that its 23 years of experience and leadership in providing the highest quality clinical care and research, combined with innovative strategies for community outreach will offer important scientific and operational contributions to the ATN. The Specific Aims of the AAP's participation in the ATN are to: 1) contribute to the advancement of the scientific agenda of the ATN through participating in protocol teams, writing/reviewing protocols and research papers and disseminating of key findings; 2) advance HIV prevention and care by recruiting and retaining HIV+ and at-risk youth ages 13-24 years into all relevant ATN trials; 3) provide a comprehensive array of clinical and mental health services to youth to facilitate their clinical care and enrollment into trials while ensuring their rights and safety as research volunteers; 4) contribute to the prevention of HIV via Connect to Protect innovative outreach prevention strategies and community mobilization and structural change such as the Bronx Knows and 5) contribute to the effective operations of the ATN via participation in calls, meetings and committees. The goals of the RFA include the development and implementation of behavioral, community-based and translational, prophylactic, therapeutic and vaccine trials with HIV+ and at-risk youth. The success of these intervention studies will facilitate better clinical and behavioral management for HIV infected youth as well as make a significant contribution to the prevention of HIV infection among youth. The AAP is uniquely positioned to meet these goals both through experience as well as its population of HIV positive and at-risk youth living in the Bronx, NY. In 2009, the AAP cared for 134 HIV+ patients, 62% male and 98% ethnic/racial minorities. The heavy burden of HIV faced by Bronx residents and youth necessitates continued research. As the borough with the poorest congressional district in the nation, the health status of the 1.3 million Bronx residents continues to lag behind other residents of NYC. Participation in the ATN will help the AAP to continue to address the public health issues of HIV/AIDS in the Bronx, NY. RELEVANCE: Adolescents from communities of color as well as young men who have sex with men continue to experience disproportionate rates of HIV infection. A clinical trials network which addresses research to the care and prevention needs of these youth is crucial for addressing the HIV epidemic. The Adolescent AIDS Program represents a high quality clinical and research site in the heavily impacted community of the Bronx, NY.