ADOLESCENT MEDICINE TRIALS UNIT

描述(由申请人提供)：纽约州布朗克斯阿尔伯特·爱因斯坦医学院蒙蒂菲奥里医学中心的青少年艾滋病计划(AAP)正在重新竞争成为青少年医学试验单位，以在青少年医学艾滋病毒/艾滋病干预试验网络(ATN)中实施临床和行为研究。自1987年以来，AAP的使命一直是为感染艾滋病毒和有感染艾滋病毒风险的青少年提供全面的护理和预防服务。AAP相信，其在提供最高质量的临床护理和研究方面的经验和领导地位，以及社区推广的创新战略，将为NIH在RFA中提出的研究议程提供重要的科学和业务贡献。青少年艾滋病项目参与ATN的具体目标是：1.通过参与方案小组、撰写/审查方案和研究论文以及传播关键发现，促进ATN的科学议程的推进。2.通过参加电话会议和委员会，为ATN的有效运作做出贡献。3.向青年提供全面的临床和精神卫生服务，促进他们的临床护理和参加试验，同时确保他们作为研究志愿者的权利和安全。4.通过招募和留住13至24岁的艾滋病毒阳性和高危青少年参加所有相关的ATN试验，促进艾滋病毒的预防和护理。5.通过社区动员和结构改革，通过连接到保护(R)和其他创新的外联和预防战略，为预防艾滋病毒作出贡献。RFA的目标包括开发和实施针对艾滋病毒感染者和高危青年的行为、基于社区的转化、预防、治疗和疫苗试验。这些干预研究的成功将有助于对感染艾滋病毒的青年进行更好的临床和行为管理，并为预防青年进一步感染艾滋病毒作出重大贡献。AAP通过其研究和临床经验以及居住在纽约布朗克斯的艾滋病毒阳性和高危青年人口，处于实现这些目标的独特地位。2004年，AAP照顾了101名艾滋病毒携带者青年(其中60%是女性，98%是少数族裔)。布朗克斯居民和青年面临艾滋病毒的沉重负担，因此有必要继续开展研究，以制定更有效的预防、病例发现和护理方法。作为贫困率最高的行政区，布朗克斯130万居民的健康状况继续落后于纽约市的其他居民。布朗克斯区感染艾滋病毒/艾滋病的人数比45个州还多。这项研究将有助于AAP解决布朗克斯区艾滋病毒/艾滋病的公共卫生问题。

DESCRIPTION (provided by applicant): The Adolescent AIDS Program (AAP) at Montefiore Medical Center, Albert Einstein College of Medicine, the Bronx, NY is re-competing to be an Adolescent Medicine Trials Unit to implement clinical and behavioral studies in the Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN). Since 1987, the mission of the AAP has been to provide comprehensive care and prevention services to adolescents living with and at-risk for HIV infection. The AAP believes that its experience and leadership in providing the highest quality clinical care and research, combined with innovative strategies for community outreach will offer important scientific and operational contributions to the research agenda posed in the RFA by the NIH. The Specific Aims of the Adolescent AIDS Program's participation in the ATN are: 1. To contribute to the advancement of the scientific agenda of the ATN through participation in protocol teams, writing/reviewing protocols and research papers and dissemination of key findings. 2. To contribute to the effective operations of the ATN via participation in calls, meetings and committees. 3. To provide a comprehensive array of clinical and mental health services to youth to facilitate their clinical care and enrollment into trials while ensuring their rights and safety as research volunteers. 4. To advance HIV prevention and care by recruiting and retaining HIV positive and at-risk adolescents ages 13 through 24 years into all relevant ATN trials. 5.To contribute to the prevention of HIV via community mobilization and structural change via Connect to Protect (r) and other innovative outreach and prevention strategies. The goals of the RFA include the development and implementation of behavioral, community-based translational, prophylactic, therapeutic and vaccine trials with HIV-infected and at risk youth. The success of these intervention studies will facilitate better clinical and behavioral management for HIV infected youth as well as make a significant contribution to the prevention of further HIV infection among youth. The AAP is uniquely positioned to meet these goals both through its research and clinical experience as well as its population of HIV positive and at-risk youth who reside in the Bronx, New York. In 2004, the AAP cared for101 HIV+ youth (60% of whom are females and 98% of whom are ethnic/racial minorities). The heavy burden of HIV faced by Bronx residents and youth necessitates continued research to develop more effective approaches to prevention, case finding and care. As the borough with the highest rates of poverty, the health status of the 1.3 million Bronx residents continues to lag behind other residents of New York City. The Bronx has more people living with HIV/AIDS than 45 states. This research will help the AAP to address the public health issue of HIV/AIDS in the Bronx.