ADOLESCENT MEDICINE TRIALS UNIT

青少年医学试验单位

• 批准号: 8260125
• 负责人: Donna Futterman
• 金额: $ 87.25万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-04-16 至 2016-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8260125
• 关键词: AIDS prevention; AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Address; Adolescent; Adolescent Medicine; Adolescent Medicine Trials Network; Age; Behavioral; Caring; Clinical; Clinical Research; Clinical Trials Network; Color; Communities; Community Outreach; Development; Enrollment; Ensure; Epidemic; Goals; HIV; HIV Infections; HIV Seropositivity; Health Status; Intervention; Intervention Studies; Leadership; Life; Medical center; Medicine; Mental Health Services; Minority Groups; Paper; Patients; Population; Positioning Attribute; Prevention; Prevention strategy; Protocols documentation; Public Health; Recruitment Activity; Research; Rights; Risk; Safety; Writing; Youth; base; clinical care; clinical research site; college; experience; innovation; male; meetings; men who have sex with men; operation; outreach; programs; prophylactic; success; therapeutic vaccine; volunteer

DESCRIPTION (provided by applicant): The Adolescent AIDS Program (AAP) at Montefiore Medical Center, Einstein College of Medicine, in the Bronx, NY is re-competing to be an Adolescent Medicine Trials Unit to implement clinical and behavioral Studies in the Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN). The AAP believes that its 23 years of experience and leadership in providing the highest quality clinical care and research, combined with innovative strategies for community outreach will offer important scientific and operational contributions to the ATN. The Specific Aims of the AAP's participation in the ATN are to: 1) contribute to the advancement of the scientific agenda of the ATN through participating in protocol teams, writing/reviewing protocols and research papers and disseminating of key findings; 2) advance HIV prevention and care by recruiting and retaining HIV+ and at-risk youth ages 13-24 years into all relevant ATN trials; 3) provide a comprehensive array of clinical and mental health services to youth to facilitate their clinical care and enrollment into trials while ensuring their rights and safety as research volunteers; 4) contribute to the prevention of HIV via Connect to Protect innovative outreach prevention strategies and community mobilization and structural change such as the Bronx Knows and 5) contribute to the effective operations of the ATN via participation in calls, meetings and committees. The goals of the RFA include the development and implementation of behavioral, community-based and translational, prophylactic, therapeutic and vaccine trials with HIV+ and at-risk youth. The success of these intervention studies will facilitate better clinical and behavioral management for HIV infected youth as well as make a significant contribution to the prevention of HIV infection among youth. The AAP is uniquely positioned to meet these goals both through experience as well as its population of HIV positive and at-risk youth living in the Bronx, NY. In 2009, the AAP cared for 134 HIV+ patients, 62% male and 98% ethnic/racial minorities. The heavy burden of HIV faced by Bronx residents and youth necessitates continued research. As the borough with the poorest congressional district in the nation, the health status of the 1.3 million Bronx residents continues to lag behind other residents of NYC. Participation in the ATN will help the AAP to continue to address the public health issues of HIV/AIDS in the Bronx, NY. RELEVANCE: Adolescents from communities of color as well as young men who have sex with men continue to experience disproportionate rates of HIV infection. A clinical trials network which addresses research to the care and prevention needs of these youth is crucial for addressing the HIV epidemic. The Adolescent AIDS Program represents a high quality clinical and research site in the heavily impacted community of the Bronx, NY.

描述（由申请人提供）：青少年艾滋病计划（AAP）在蒙蒂菲奥里医疗中心，爱因斯坦医学院，在纽约州布朗克斯是重新竞争成为一个青少年医学试验单位，以实施临床和行为研究的青少年医学试验网络艾滋病毒/艾滋病干预措施（ATN）。AAP认为，其23年的经验和领导力，提供最高质量的临床护理和研究，结合创新的社区外展战略，将提供重要的科学和业务贡献的ATN。澳大利亚艾滋病学会参加艾滋病网络的具体目标是：1）通过参加方案小组、编写/审查方案和研究论文以及传播关键研究结果，促进艾滋病网络科学议程的进步; 2）通过招募和留住13-24岁艾滋病毒阳性和高危青年参加所有相关的艾滋病网络试验，促进艾滋病毒预防和护理; 3）为青年提供全面的临床和心理健康服务，以促进他们的临床护理和参加试验，同时确保他们作为研究志愿者的权利和安全; 4）通过“连接以保护”创新的外展预防战略和社区动员以及结构变革，如“布朗克斯知道”，为预防艾滋病毒做出贡献;通过参加电话、会议和委员会，为ATN的有效运作做出贡献。RFA的目标包括制定和实施艾滋病毒阳性和高危青年的行为、社区和转化、预防、治疗和疫苗试验。这些干预研究的成功将有助于更好地为感染艾滋病毒的青少年提供临床和行为管理，并对预防青少年感染艾滋病毒作出重大贡献。AAP具有独特的优势，可以通过其经验以及居住在纽约布朗克斯的艾滋病毒阳性和高危青年人口来实现这些目标。2009年，AAP照顾了134名艾滋病毒阳性患者，其中62%为男性，98%为少数民族/种族。布朗克斯居民和青年面临的艾滋病毒的沉重负担需要继续研究。作为全国最贫穷的国会选区，130万布朗克斯居民的健康状况继续落后于纽约市的其他居民。参与ATN将有助于AAP继续解决纽约布朗克斯的艾滋病毒/艾滋病公共卫生问题。 相关性：来自有色人种社区的青少年以及男男性行为的年轻男子继续经历不成比例的艾滋病毒感染率。一个临床试验网络，解决这些青年的护理和预防需要的研究，是解决艾滋病毒流行病的关键。青少年艾滋病项目是纽约州布朗克斯受影响严重的社区的一个高质量的临床和研究场所。