ADOLESCENT MEDICINE TRIALS UNIT

青少年医学试验单位

• 批准号: 8528639
• 负责人: Donna Futterman
• 金额: $ 85.45万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-04-16 至 2016-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8528639
• 关键词: AIDS prevention; AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Address; Adolescent; Adolescent Medicine; Adolescent Medicine Trials Network; Age; Behavioral; Caring; Clinical; Clinical Research; Clinical Trials Network; Color; Communities; Community Outreach; Development; Enrollment; Ensure; Epidemic; Goals; HIV; HIV Infections; HIV Seropositivity; Health Status; Intervention; Intervention Studies; Leadership; Life; Medical center; Medicine; Mental Health Services; Minority Groups; Paper; Patients; Population; Positioning Attribute; Prevention; Prevention strategy; Protocols documentation; Public Health; Recruitment Activity; Research; Rights; Risk; Safety; Writing; Youth; base; clinical care; clinical research site; college; experience; innovation; male; meetings; men who have sex with men; operation; outreach; programs; prophylactic; success; therapeutic vaccine; volunteer

DESCRIPTION (provided by applicant): The Adolescent AIDS Program (AAP) at Montefiore Medical Center, Einstein College of Medicine, in the Bronx, NY is re-competing to be an Adolescent Medicine Trials Unit to implement clinical and behavioral Studies in the Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN). The AAP believes that its 23 years of experience and leadership in providing the highest quality clinical care and research, combined with innovative strategies for community outreach will offer important scientific and operational contributions to the ATN. The Specific Aims of the AAP's participation in the ATN are to: 1) contribute to the advancement of the scientific agenda of the ATN through participating in protocol teams, writing/reviewing protocols and research papers and disseminating of key findings; 2) advance HIV prevention and care by recruiting and retaining HIV+ and at-risk youth ages 13-24 years into all relevant ATN trials; 3) provide a comprehensive array of clinical and mental health services to youth to facilitate their clinical care and enrollment into trials while ensuring their rights and safety as research volunteers; 4) contribute to the prevention of HIV via Connect to Protect innovative outreach prevention strategies and community mobilization and structural change such as the Bronx Knows and 5) contribute to the effective operations of the ATN via participation in calls, meetings and committees. The goals of the RFA include the development and implementation of behavioral, community-based and translational, prophylactic, therapeutic and vaccine trials with HIV+ and at-risk youth. The success of these intervention studies will facilitate better clinical and behavioral management for HIV infected youth as well as make a significant contribution to the prevention of HIV infection among youth. The AAP is uniquely positioned to meet these goals both through experience as well as its population of HIV positive and at-risk youth living in the Bronx, NY. In 2009, the AAP cared for 134 HIV+ patients, 62% male and 98% ethnic/racial minorities. The heavy burden of HIV faced by Bronx residents and youth necessitates continued research. As the borough with the poorest congressional district in the nation, the health status of the 1.3 million Bronx residents continues to lag behind other residents of NYC. Participation in the ATN will help the AAP to continue to address the public health issues of HIV/AIDS in the Bronx, NY. RELEVANCE: Adolescents from communities of color as well as young men who have sex with men continue to experience disproportionate rates of HIV infection. A clinical trials network which addresses research to the care and prevention needs of these youth is crucial for addressing the HIV epidemic. The Adolescent AIDS Program represents a high quality clinical and research site in the heavily impacted community of the Bronx, NY.

描述(由申请人提供)：纽约布朗克斯区爱因斯坦医学院蒙蒂菲奥里医学中心的青少年艾滋病计划(AAP)正在重新竞争成为青少年医学试验单位，在青少年医学艾滋病毒/艾滋病干预试验网络(ATN)中实施临床和行为研究。AAP相信，其23年来在提供最高质量的临床护理和研究方面的经验和领导地位，加上社区外展的创新战略，将为ATN做出重要的科学和业务贡献。AAP参与ATN的具体目的是：1)通过参加方案小组、编写/审查方案和研究论文以及传播关键结果，促进ATN的科学议程；2)通过招募和留住13-24岁的艾滋病毒阳性和高危青年参加所有相关的ATN试验，促进艾滋病毒的预防和护理；3)向青年提供全面的临床和精神卫生服务，以促进他们的临床护理和登记参加试验，同时确保他们作为研究志愿者的权利和安全；4)通过Connect帮助预防艾滋病毒，以保护创新的外展预防战略以及社区动员和结构变化，如布朗克斯Knows；5)通过参与电话会议和委员会，促进ATN的有效运作。RFA的目标包括开发和实施针对HIV+和高危青少年的行为、社区和转化性、预防性、治疗性和疫苗试验。这些干预研究的成功将有助于对感染艾滋病毒的青年进行更好的临床和行为管理，并为预防青年感染艾滋病毒作出重大贡献。AAP处于独特的地位，可以通过经验以及居住在纽约布朗克斯的艾滋病毒阳性和高危青年人口来实现这些目标。2009年，AAP照顾了134名HIV+患者，其中62%是男性，98%是少数民族。布朗克斯居民和青年面临沉重的艾滋病毒负担，需要继续研究。作为全国拥有最贫穷国会选区的行政区，布朗克斯130万居民的健康状况继续落后于纽约市的其他居民。参加ATN将有助于AAP继续解决纽约州布朗克斯区艾滋病毒/艾滋病的公共卫生问题。 相关性：来自有色人种社区的青少年以及与男性发生性行为的年轻男性继续经历不成比例的艾滋病毒感染率。针对这些青年的护理和预防需求进行研究的临床试验网络对解决艾滋病毒流行病至关重要。青少年艾滋病计划代表了纽约州布朗克斯区受影响严重的社区的高质量临床和研究网站。