Clinical Research Career Development Program

描述(由申请人提供)：这是一项续签K-12补助金的建议，该补助金为Dana Farber/哈佛癌症中心(DF/HCC)多学科临床研究项目(包括外科、放射肿瘤学、内科和儿科肿瘤学)的五名高级研究员或初级教员提供翻译研究职业发展的支持。DF/HCC是由哈佛医学院(HMS)、哈佛公共卫生学院(HSPH)和初级HMS教学医院组成的联合体，包括达纳-法伯癌症研究所(DFCI)、布里格姆妇女医院(BWH)、马萨诸塞州综合医院(MGH)、贝丝以色列女执事医院(BID)和儿童医院(CH)。这项提议将支持医生研究人员在奖学金后培训和职业发展的关键年份，目的是将癌症生物学的应用应用于癌症治疗。因此，培训计划的重点是为开发针对血管生成、信号转导和激活的生长因子途径、DNA修复缺陷和其他肿瘤生物学特征的新药物的独立职业做准备。根据以前的实验室经验，候选人将接受与其临床兴趣相关的实验室培训，如分子肿瘤学和遗传学、药代动力学或临床免疫学，以及生物统计学和临床试验设计的教学课程，作为其发展计划的一部分。每个参与者将设计和管理临床试验，以表达其生物学兴趣的特定重点。我们的K12咨询委员会将仔细监测候选人的进步，包括研究效率、教学准备以及生物统计学、临床和实验室研究人员的指导。咨询委员会将由来自主要临床学科(内科和儿科肿瘤学、外科和放射肿瘤学)、基础科学、转化研究、生物统计学和临床试验管理的教职员工组成。获奖者的进展将通过学员和导师的定期书面报告、学员的研究研讨会和对已发表作品的审查来监测。我们将通过我们的癌症中心消除癌症差异倡议，积极招募女性和少数族裔候选人的申请。与公共卫生的相关性：该项目有助于培训年轻医生，为未来的临床研究生涯做准备，并增强他们在癌症治疗方面的知识和专长。

DESCRIPTION (provided by applicant): This is a proposal to renew a K-12 grant that provides support for career development in translational research for five senior fellows or junior faculty members in the multidisciplinary clinical research programs (including surgery, radiation oncology, and medical and pediatric oncology) of the Dana Farber/Harvard Cancer Center (DF/HCC). The DF/HCC is a consortium of Harvard Medical School (HMS), the Harvard School of Public Health (HSPH), and the primary HMS teaching hospitals, including the Dana-Farber Cancer Institute (DFCI), Brigham and Women's Hospital (BWH), Massachusetts General Hospital (MGH), Beth Israel-Deaconess Hospital (BID), and The Children's Hospital (CH). This proposal would support physician investigators during critical years of post fellowship training and career development, with the intent of their bringing applications of cancer biology into use for treating cancer. Thus the training program focuses on preparing for independent careers in the development of new agents targeted against angiogenesis, signal transduction and activated growth factor pathways, DNA repair defects, and other features of tumor biology. Depending on prior laboratory experience, candidates will pursue laboratory training related to their clinical interests, as in molecular oncology and genetics, pharmacokinetics, or clinical immunology, as well as didactic coursework in biostatistics and clinical trial design, as part of their development plan. Each participant will design and manage clinical trials that express the particular focus of his/her biological interest. Our K12 Advisory Committee will carefully monitor candidate's progress including research productivity didactic preparation, and mentorship by biostatistical, clinical and laboratory investigators. The advisory committee will be composed of faculty from the major clinical disciplines (medical and pediatric oncology, surgery, and radiation oncology), basic science, translational research, biostatistics, and clinical trials management. Progress of awardees will be monitored through regular written reports from trainees and mentors, research seminars presented by trainees, and a review of published work. We will aggressively recruit applications from women and minority candidates through our Cancer Center's Initiative to Eliminate Disparities in Cancer. Relevance to public health: This project helps to train young physicians for a future career in clinical research and to enhance their knowledge and expertise in the treatment of cancer.