Clinical Research Career Development Program

描述（由申请人提供）：这是一项更新K-12补助金的提案，该补助金为达纳法伯/哈佛癌症中心（DF/HCC）多学科临床研究项目（包括外科手术，放射肿瘤学以及医学和儿科肿瘤学）的五名高级研究员或初级教员的转化研究职业发展提供支持。DF/HCC是由哈佛医学院（HMS）、哈佛公共卫生学院（HSPH）和主要的HMS教学医院组成的联盟，包括丹娜-法伯癌症研究所（DFCI）、布里格姆妇女医院（BWH）、马萨诸塞州总医院（MGH）、贝斯以色列女执事医院（BID）和儿童医院（CH）。该提案将在研究金后培训和职业发展的关键年份支持医生研究人员，目的是将癌症生物学应用于治疗癌症。因此，培训计划的重点是为开发针对血管生成，信号转导和活化生长因子途径，DNA修复缺陷和肿瘤生物学其他特征的新药物的独立职业做准备。根据以前的实验室经验，候选人将追求与他们的临床兴趣相关的实验室培训，如分子肿瘤学和遗传学，药代动力学或临床免疫学，以及生物统计学和临床试验设计的教学课程，作为他们发展计划的一部分。每个参与者将设计和管理临床试验，表达他/她的生物学兴趣的特定焦点。我们的K12咨询委员会将仔细监控候选人的进展，包括研究生产力教学准备，以及生物统计，临床和实验室研究人员的指导。咨询委员会将由来自主要临床学科（医学和儿科肿瘤学，外科学和放射肿瘤学），基础科学，转化研究，生物统计学和临床试验管理的教师组成。将通过学员和导师的定期书面报告、学员举办的研究研讨会以及对已发表作品的审查来监测获奖者的进展情况。我们将通过我们的癌症中心消除癌症差异倡议积极招募女性和少数族裔候选人的申请。与公共卫生的相关性：该项目有助于培训年轻医生从事临床研究，并提高他们在治疗癌症方面的知识和专业知识。

DESCRIPTION (provided by applicant): This is a proposal to renew a K-12 grant that provides support for career development in translational research for five senior fellows or junior faculty members in the multidisciplinary clinical research programs (including surgery, radiation oncology, and medical and pediatric oncology) of the Dana Farber/Harvard Cancer Center (DF/HCC). The DF/HCC is a consortium of Harvard Medical School (HMS), the Harvard School of Public Health (HSPH), and the primary HMS teaching hospitals, including the Dana-Farber Cancer Institute (DFCI), Brigham and Women's Hospital (BWH), Massachusetts General Hospital (MGH), Beth Israel-Deaconess Hospital (BID), and The Children's Hospital (CH). This proposal would support physician investigators during critical years of post fellowship training and career development, with the intent of their bringing applications of cancer biology into use for treating cancer. Thus the training program focuses on preparing for independent careers in the development of new agents targeted against angiogenesis, signal transduction and activated growth factor pathways, DNA repair defects, and other features of tumor biology. Depending on prior laboratory experience, candidates will pursue laboratory training related to their clinical interests, as in molecular oncology and genetics, pharmacokinetics, or clinical immunology, as well as didactic coursework in biostatistics and clinical trial design, as part of their development plan. Each participant will design and manage clinical trials that express the particular focus of his/her biological interest. Our K12 Advisory Committee will carefully monitor candidate's progress including research productivity didactic preparation, and mentorship by biostatistical, clinical and laboratory investigators. The advisory committee will be composed of faculty from the major clinical disciplines (medical and pediatric oncology, surgery, and radiation oncology), basic science, translational research, biostatistics, and clinical trials management. Progress of awardees will be monitored through regular written reports from trainees and mentors, research seminars presented by trainees, and a review of published work. We will aggressively recruit applications from women and minority candidates through our Cancer Center's Initiative to Eliminate Disparities in Cancer. Relevance to public health: This project helps to train young physicians for a future career in clinical research and to enhance their knowledge and expertise in the treatment of cancer.