CSHL Conference on Mouse Molecular Genetics: Development & Disease

描述(申请人提供)：老鼠无疑是各种哺乳动物研究的首选遗传系统。利用小鼠作为模型系统在许多不同的领域取得了重大进展，特别是在发育生物学、免疫学、血液学、神经生物学和肿瘤学方面。在过去的20年里，小鼠的实验研究有了显著的增长，这主要是由于惊人的技术和概念的发展，最终在2007年诺贝尔生理学或医学奖被授予三位小鼠遗传学家，因为他们发现了利用胚胎干细胞在小鼠身上引入特定基因修改的原理。这项会议申请寻求对年度系列会议中第二十一次会议的支持，这些会议已成为该领域的主要会议。该系列会议在冷泉港和欧洲地点之间交替举行，2008年的会议将在冷泉港实验室举行。拟召开的“老鼠遗传学和基因组学：发育和疾病”会议将召集该领域的领导者、初级教师、博士后研究员和研究生讨论最新研究，并分享该领域最新前沿发展的信息。2008年会议将讨论的议题将包括疾病模型、神经生物学、生殖细胞和干细胞、表观遗传学、图案化、器官发生、遗传学和基因组学。鉴于目前在这一领域采用的方法多种多样，工作者之间的交流对于促进研究和了解哺乳动物发育的基本过程以及这些过程如何在各种疾病中受到干扰至关重要。口头发言将由会议主席与组织者协商后选定。每一次会议都将由该领域的两位顶尖科学家主持。选定的演讲者将包括研究生、博士后研究员和初级教员。会议将以纪念已故罗莎·贝丁顿的特别讲座开始。还将有两到三个海报会议，大多数参与者可以展示他们的作品。这次会议将是中等规模的，我们预计将有300-350名老鼠遗传学家和基因学家出席。

DESCRIPTION (provided by applicant): The mouse is undoubtedly the premiere genetic system for a variety of mammalian studies. Significant advances have been made in a number of diverse fields using the mouse as a model system, in particular, in developmental biology, immunology, hematology, neurobiology, and oncology. Over the last two decades, there has been a dramatic increase in experimental studies in the mouse, largely as a result of striking technical and conceptual developments, culminating in the 2007 Nobel prize in physiology or medicine being awarded to three mouse geneticists "for their discoveries of principles for introducing specific gene modifications in mice by the use of embryonic stem cells". This conference application seeks support for the twenty-first of an annual series of meetings that has emerged as the premiere meeting for this field. The meeting series alternates between Cold Spring Harbor and a European venue, with the 2008 meeting to be held at the Cold Spring Harbor Laboratory. The proposed meeting on "Mouse Genetics & Genomics: Development & Disease" will assemble leaders in the field, junior faculty, postdoctoral fellows, and graduate students to discuss the latest research and to share information about new cutting-edge developments in the field. Topics to be discussed for the 2008 meeting will include Disease Models; Neurobiology; Germ Cells and Stem Cells; Epigenetics; Patterning; Organogenesis; Genetics; and Genomics. Given the diverse approaches currently employed in this field, communication among workers is essential to advance research and understanding of fundamental processes in mammalian development, and how these processes are disrupted in a variety of diseases. Oral presentations will be selected by the session chairs in consultation with the organizers. Each session will be chaired by two leading scientists in the field. Selected speakers will include graduate students, postdoctoral fellows, and junior faculty. The meeting will commence with a special lecture in honor of the late Rosa Beddington. There will also be two or three poster sessions where a majority of participants can present their work. The meeting will be of moderate size, and we expect 300-350 mouse geneticists and genomicists are expected in attendance.