EVALUATION OF VERVETS AS A RESEARCH MODEL FOR ASSISTED REPRODUCTIVE TECHNOLGIES

长尾黑颚猴作为辅助生殖技术研究模型的评估

• 批准号: 7561918
• 负责人: SHOUKHRAT M MITALIPOV
• 金额: $ 1.47万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7561918
• 关键词: Anovulation; Assisted Reproductive Technology; Caribbean natives; Caribbean region; Cervix Uteri; Characteristics; Computer Retrieval of Information on Scientific Projects Database; Embryo; Embryonic Development; Evaluation; Fertilization; Funding; Grant; Health; Human; Human Development; Institution; Intracytoplasmic Sperm Injections; Macaca mulatta; Modeling; Numbers; Oocytes; Primates; Research; Research Personnel; Resources; Source; United States National Institutes of Health; base; cost; reproductive; sperm cell; vervet

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The rhesus macaque has been used extensively as a model for early human development and for fertilization and embryonic development in primates. Over the past 20 years, remarkable advancements in the assisted reproductive technologies (ARTs) have been achieved using the rhesus monkey model. Several of these accomplishments, including multiple follicle stimulation, oocyte fertilization by intracytoplasmic sperm injection, and oocyte/embryo manipulation, were recently described. However, owing to their limited supply and great value in other research efforts, rhesus monkeys are increasingly difficult and expensive to acquire. Therefore, the Caribbean vervet was evaluated as a primate model for ARTs based on general health, availability, cost, lack of seasonal anovulation, straight cervix, and human-like sperm characteristics. For a particular species such as the vervet to serve as an alternative model for the rhesus macaque and for studying the ARTs, the ability to obtain a high number of healthy, fertilizable oocytes, collect and cryopreserve fertile spermatozoa, as well as cryopreserve and transfer the resulting embryos when a recipient is available would be essential.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 恒河猴已被广泛用作早期人类发育以及灵长类动物受精和胚胎发育的模型。 过去 20 年来，利用恒河猴模型在辅助生殖技术 (ART) 方面取得了显着进步。 最近描述了其中的一些成就，包括多卵泡刺激、胞浆内精子注射卵母细胞受精以及卵母细胞/胚胎操作。 然而，由于恒河猴的供应有限且在其他研究工作中具有巨大价值，因此获取恒河猴变得越来越困难和昂贵。 因此，根据一般健康状况、可用性、成本、缺乏季节性不排卵、直子宫颈和类人精子特征，将加勒比长尾黑颚猴评估为ART的灵长类动物模型。 对于长尾黑颚猴等特定物种作为恒河猴和研究 ART 的替代模型来说，获得大量健康、可受精卵母细胞、收集和冷冻保存可育精子、以及在有受体时冷冻保存和移植所得胚胎的能力至关重要。