ANDROGEN EXPOSURE AND ACTIONS IN PRE- TO PERIPUBERTAL MONKEYS

青春期前猴子的雄激素暴露和作用

• 批准号: 7561932
• 负责人: JUDY L CAMERON
• 金额: $ 1.47万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7561932
• 关键词: Age at Menarche; American; Androgens; Anovulation; Antral; Chronic; Computer Retrieval of Information on Scientific Projects Database; Disease; Etiology; Exposure to; Feedback; Female; Female Adolescents; Frequencies; Funding; Goals; Gonadotropin Hormone Releasing Hormone; Grant; Hyperandrogenism; Infertility; Institution; Insulin Resistance; Knowledge; Luteinizing Hormone; Macaca mulatta; Menarche; Menstrual cycle; Modeling; Monkeys; Neurosecretory Systems; Numbers; Oligonucleotides; Ovarian; Ovary; Physiologic pulse; Pituitary Gland; Prevention; Primates; Progesterone; Puberty; Pulse taking; Research; Research Personnel; Resources; Source; Steroids; Symptoms; Syndrome; Testosterone; United States National Institutes of Health; Woman; indexing; size

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Polycystic Ovarian Syndrome (PCOS) is a common disorder of hyperandrogenism and oligo/anovulation, causing infertility in 4-8% of American women. The etiology of PCOS remains controversial. Though insulin resistance is considered one cause of PCOS, correlative evidence suggests that exposure to increased levels of androgens (from the ovaries) before and during puberty may be a primary cause of many PCOS symptoms. The goal of this project is to determine whether chronic exposure to elevated levels of testosterone (T), found in adolescent girls predisposed to PCOS, will cause changes in the neuroendocrine-ovarian axis in peri-pubertal female rhesus macaques that are reminiscent of PCOS. Ovarian parameters include age at menarche, occurrence of normal menstrual cycles, and numbers/sizes of antral follicles in the ovaries. Neuroendocrine indices will include the frequency and amplitude of circulating luteinizing hormone (LH) pulses secreted by the pituitary gland, sensitivity of LH secretion to exogenous gonadotropin-releasing hormone (GnRH), and steroid (exogenous progesterone) feedback inhibition of LH secretion after menarche. This project will greatly increase our knowledge of the effects of elevated androgen exposure in female adolescents, and possibly develop a primate model for better understanding of the causes, prevention and treatment of PCOS in women.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 多囊卵巢综合征（PCOS）是一种常见的和寡素/无卵形的常见疾病，在4-8％的美国女性中导致不孕症。 PCOS的病因仍然存在争议。 尽管胰岛素抵抗被认为是PCOS的一种原因，但相关证据表明，在青春期和青春期之前和期间，雄激素（来自卵巢）的水平升高可能是许多PCOS症状的主要原因。 该项目的目的是确定在易​​于PCOS的青少年女孩中发现的长期暴露于睾丸激素水平升高（t）是否会导致Puserbertal雌性恒河猕猴的神经内分泌 - 伏安型轴的变化，这些猕猴会回想起PCOS。 卵巢参数包括初潮时代的年龄，正常的月经周期的发生以及卵巢中鼻卵泡的数量/尺寸。 神经内分泌指标将包括垂体分泌的循环黄体激素（LH）脉冲的频率和幅度，LH分泌对外源性促性腺激素释放激素（GNRH）的敏感性，以及类固醇（异源质子酯）反馈抑制LH的含量，后者均延迟了Menarch。 该项目将大大提高我们对女性青少年雄激素暴露升高的影响的了解，并可能开发出一种灵长类动物模型，以更好地了解女性PCOS的原因，预防和治疗。