RAPID MIXING SYSTEM FLOW CYTOMETER

快速混合系统流式细胞仪

• 批准号: 7724224
• 负责人: STEVEN W GRAVES
• 金额: $ 1.61万
• 依托单位: LOS ALAMOS NAT SECTY-LOS ALAMOS NAT LAB
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7724224
• 关键词: Adhesions; Biological; Biological Assay; Cell Surface Receptors; Cells; Computer Retrieval of Information on Scientific Projects Database; Devices; Flow Cytometry; Funding; Grant; Institution; Kinetics; Ligands; Link; Reaction; Research; Research Personnel; Resolution; Resources; Signal Transduction; Source; System; Time; United States National Institutes of Health; instrument; millisecond

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We have developed a stopped-flow flow cytometer with subsecond resolution to be used in kinetic analysis of cell activation. This instrument is extending the application of flow cytometry to important biological molecules that interact with cell surface receptors or can be linked to beads. The device is operational, and can be used for reactions to100 msec time resolution. It is presently being used for analysis of adhesion and signal transduction ligands and enzymatic assays.

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