MAGN FIELD &TISSUE DEPENDENCIES OF HUMAN BRAIN LONGITUDINAL 1H2O RELAX IN VIVO

磁场

• 批准号: 7721361
• 负责人: SEONG KIM
• 金额: $ 1.78万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-01 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7721361
• 关键词: Blood; Brain; Cerebrospinal Fluid; Computer Retrieval of Information on Scientific Projects Database; Dependency; Detection; Funding; Grant; Human; Individual; Institution; Iron; Magnetic Resonance Imaging; Personal Satisfaction; Protons; Range; Reagent; Relaxation; Research; Research Personnel; Resolution; Resources; Sampling; Slice; Source; Standards of Weights and Measures; Techniques; Time; Tissues; United States National Institutes of Health; Ventricular; Water; brain tissue; in vivo; magnetic field; simulation; white matter

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Brain water proton (1H2O) longitudinal relaxation time constants (T1) were obtained from three healthy individuals at magnetic field strengths (B0) of 0.2 Tesla (T), 1.0T, 1.5T, 4.0T, and 7.0T. A 5-mm midventricular axial slice was sampled using a modified Look-Locker technique with 1.5 mm in-plane resolution, and 32 time points post-adiabatic inversion. The results confirmed that for most brain tissues, T1 values increased by more than a factor of 3 between 0.2T and 7T, and over this range were well fitted by T1 (s)=0.583(B0)0.382, T1(s)=0.857(B0)0.376, and T1(s)=1.35(B0)0.340 for white matter (WM), internal GM, and blood 1H2O, respectively. The ventricular cerebrospinal fluid (CSF) 1H2O T1 value did not change with B0, and its average value (standard deviation (SD)) across subjects and magnetic fields was 4.3 (+/-0.2) s. The tissue 1/T1 values at each field were well correlated with the macromolecular mass fraction, and to a lesser extent tissue iron content. The field-dependent increases in 1H2O T1 values more than offset the well-known decrease in typical MRI contrast reagent (CR) relaxivity, and simulations predict that this leads to lower CR concentration detection thresholds with increased magnetic field.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 脑水质子（1H2O）纵向松弛时间常数（T1）是从磁场强度（B0）的三个健康个体中获得的0.2 Tesla（T），1.0T，1.0T，1.5T，4.0T和7.0T。使用具有1.5 mm面内分辨率的改良外观锁定技术和32个时间点后，对室内轴向切片进行了5毫米的中间轴向切片。结果证实，对于大多数脑组织，T1值在0.2t和7t之间增加了3倍以上，并且在此范围内，T1（s）= 0.583（b0）0.382，T1（s）= 0.857（b0）（b0）0.376（b0）0.376和t1（s）和t1（s）= 1.35（s）= 1.35（b0（b0）0.340 for White Mattery for White Internaly Matter Ally Brolly（wm）（wm）（wm）（wm），心室脑脊液（CSF）1H2O T1值随B0不变，其平均值（标准偏差（SD））跨受试者和磁场为4.3（+/- 0.2）s。每个磁场的组织1/T1值与大分子质量分数良好相关，并且在较小程度上组织铁含量。在1H2O T1值中，场依赖性的增加远远超过了典型的MRI对比试剂（CR）松弛性的众所周知的降低，并且模拟预测，这会导致CR浓度检测阈值随磁场增加而降低。