9.4T MR Instrument Console Upgrade

9.4T MR仪表控制台升级

• 批准号: 7790922
• 负责人: SEONG KIM
• 金额: $ 49.67万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-01-28 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7790922
• 关键词: Animals; Arts; Biomedical Research; Bite; Cell Nucleus; Computer software; Equipment; Frequencies; Funding; Future; Grant; Image; Imaging Device; Libraries; Linux; Magnetic Resonance; National Center for Research Resources; Operating System; Personal Computers; Physiologic pulse; Physiological; Protons; Research; Research Personnel; Resolution; Sampling; System; The Sun; Universities; analog; base; bioimaging; digital; in vivo; instrument; instrumentation; microsystems; pre-clinical; public health relevance

DESCRIPTION (provided by applicant): Magnetic resonance (MR) instruments provide critical noninvasive imaging tools to many biomedical researchers. The existing 9.4-T, 31-cm bore MR system, which was funded by one of the first NCRR High-End Instrumentation grant mechanisms (S10 RR17239) in 2002, was obtained from Varian Inc. (Palo Alto, CA), and delivered in February 2003. The aim of this proposal is to upgrade the analog console interfaced to our 9.4-T MR instrument with a digital-based console to better perform high-resolution animal studies at the University of Pittsburgh. This will enhance the utility of the existing 9.4-T MR console for in vivo functional and physiological studies, as well as for anatomical and pathological research. The requested digital-based DirectDrive(R) console was replaced to the analog-based INOVA(R) console, which is part of our current 9.4-T system, in 2005. Our current console must be driven by a Sun workstation with Unix operating system, which has been discontinued by Sun Microsystems, while the new digital-based console is controlled by a personal computer with Linux- based operating software. Thus, the proposed console upgrade is critical for maintaining the 9.4-T MR instrument as a state-of-the-art system in order that researchers may continue to be successful. The requested digital DirectDrive(R) Varian console has been totally redesigned and offers several major improvements over our current analog-based Varian console. The requested console has four transmitter boards for proton, one transmitter board for X-nuclei, and 4 receivers, allowing parallel imaging capabilities. The requested console has a digital receiver with 80 MHz sampling frequency, an integrated 16-bit gradient controller, digital RF pulse features, and an increased library of standard pulse sequences. The requested console upgrade will maintain the NIH-funded 9.4-T MR system as state-of-the-art equipment, which is crucial for ongoing and future biomedical imaging projects in Pittsburgh. PUBLIC HEALTH RELEVANCE: High-field magnetic resonance instrument is critically important to perform in vivo functional and physiological studies, as well as for anatomical and pathological research. The requested console upgrade will make impacts to basic and pre-clinical biomedical research.

描述（由申请人提供）：磁共振（MR）仪器为许多生物医学研究人员提供关键的无创成像工具。现有的9.4-T 31厘米MR System由2002年的第一个NCRR高端仪器赠款机制之一（S10 RR17239）资助，是从Varian Inc.（CA）获得的，并于2003年2月交付，该提案的目的是高级仪器。匹兹堡大学动物研究。这将增强现有的9.4-T MR控制台在体内功能和生理研究以及解剖学和病理学研究的实用性。所需的基于数字的Directrive（R）控制台被替换为基于模拟的Inova（R）控制台，该控制台是我们当前9.4-T系统的一部分。我们当前的控制台必须由UNIX操作系统的Sun Workstation驱动，UNIX操作系统已由Sun Sun Microsystems停用，而New Digital-Base Sune MicroSole则由New Digital Indure基于Linux的操作机构控制。因此，提议的控制台升级对于将9.4-T MR工具作为最先进的系统至关重要，以便研究人员可能会继续成功。请求的数字DirectDrive（R）Varian控制台已完全重新设计，并比我们当前基于模拟的Varian控制台提供了一些重大改进。请求的控制台具有四个用于质子的发射板，一个用于X-Nuclei的发射板和4个接收器，允许并行成像功能。请求的控制台具有具有80 MHz采样频率的数字接收器，一个集成的16位梯度控制器，数字RF脉冲功能以及增加的标准脉冲序列库。要求的控制台升级将维持NIH资助的9.4-T MR系统作为最先进的设备，这对于匹兹堡的持续和未来的生物医学成像项目至关重要。 公共卫生相关性：高场磁共振工具对于在体内功能和生理研究以及解剖学和病理研究中至关重要。请求的控制台升级将对基本和临床前生物医学研究产生影响。