University of Michigan Comprehensive Cancer Center Support Grant

密歇根大学综合癌症中心支持补助金

• 批准号: 7498747
• 负责人: MAX S. WICHA
• 金额: $ 11.4万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-06-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7498747
• 关键词: Ambulatory Care Facilities; Award; Basic Science; Behavioral; Bioinformatics; Biometry; Breast; Cancer Center; Cancer Center Support Grant; Cellular biology; Clinical; Clinical Research; Clinical Trials; Complementary DNA; Core Facility; DNA Sequence; Development; Development Plans; Evaluation; Faculty; Flow Cytometry; Funding; Goals; Grant; Growth; Head and Neck Cancer; Health Communication; Housing; Image; Immunologic Monitoring; Intervention; Journals; Laboratory Research; Leadership; Malignant Childhood Neoplasm; Medical center; Molecular; Morphology; Prevention; Prevention program; Prostate; Proteomics; Publishing; Radiation; Recruitment Activity; Research; Research Personnel; Resources; Science; Therapeutic; Tissue Procurements; Transgenic Mice; University of Michigan Comprehensive Cancer Center; animal facility; anticancer research; cancer cell; cancer genetics; cancer research center director; experience; irradiation; leukemia/lymphoma; member; molecular imaging; programs; research and development; tumor; urologic; vector

The University of Michigan Comprehensive Cancer Center (UMCCC) requests renewal of its core grant in support of Senior Leadership, Programs, and Shared Core Facilities. A core grant to support the UMCCC was initially awarded by the NCI in 1988, with continuous funding since then. Dr. Max Wicha, the founding Director of the Cancer Center, continues to serve as Director. The Center provides an organizational framework to promote interdisciplinary cancer research through the development of defined clinical, basic, and prevention programs in cancer research and the development of shared core resources. In 1997 the center moved into a new $88 million facility which houses the center's outpatient clinics as well as many of its research laboratories. The Cancer Center has continued to experience considerable growth over this grant period with 70 new faculty recruited and an 85% increase in NCI funding. The Cancer Center's 13 research programs include the basic research programs in Cancer Genetics, Cancer Cell Biology, Molecular Therapeutics, Radiation Sciences, and Molecular Imaging. Clinical research programs include Prostate/Urological, Breast, Leukemia/Lymphoma-BMT, Gl, Childhood Cancers, and Head & Neck cancers. The prevention programs include two programs: Biomedical Prevention and Socio-Behavioral. Support is requested for a total of 16 shared core facilities. These include Clinical Trials, Biostatistics, Tissue Procurement, Tumor Imaging, DNA Sequencing, Morphology, Flow Cytometry, Experimental Irradiation, Animal Facility, Transgenic Mouse, Vector Core, Immune Monitoring, cDNA Affymetrix and Microarray and three new cores including Proteomics, Bioinformatics, and Health Communications. Funds are also requested for development, planning and evaluation, and administration to support center goals. The Medical Center has made substantial commitments to the Cancer Center of approximately $175 million. Its 285 UMCCC members receive over $82 million in research funding, including over $37 million in annual direct NCI support. The UMCCC has had a major impact on cancer research as evidenced by publishing at least 315 articles in high impact journals, placing 52% of UMCCC intervention accruals onto investigator-initiated trials and consistently ranking among the top ten Cancer Centers nationally for NCI funding over this grant period.

密歇根大学综合癌症中心（UMCCC）要求更新其核心补助金， 支持高级领导、项目和共享核心设施。一项支持UMCCC的核心补助金 最初由NCI于1988年颁发，自那时以来一直持续资助。马克斯·威查博士， 癌症中心主任，继续担任主任。该中心提供了一个组织 框架，以促进跨学科的癌症研究，通过制定明确的临床，基础， 癌症研究和预防计划以及共享核心资源的开发。1997年 中心搬进了一个新的8800万美元的设施，其中包括中心的门诊诊所以及许多 他们的研究实验室。癌症中心继续经历了相当大的增长， 补助金期间，70名新教师招聘和85%的NCI资金增加。癌症中心13 研究项目包括癌症遗传学，癌细胞生物学， 分子治疗学、放射科学和分子成像。临床研究项目包括 前列腺/泌尿系统、乳腺癌、白血病/淋巴瘤-BMT、GI、儿童癌症和头颈部 癌的预防方案包括两个方案：生物医学预防和社会行为。 共请求为16个共享核心设施提供支助。这些包括临床试验，生物统计学， 组织获取，肿瘤成像，DNA测序，形态学，流式细胞术，实验 辐照，动物设施，转基因小鼠，载体核心，免疫监测，cDNA亲和层析 微阵列和三个新的核心，包括蛋白质组学，生物信息学和健康通信。 还要求为支助中心的发展、规划和评价以及行政管理提供资金 目标.医疗中心已向癌症中心作出实质性承诺， 一亿七千五百万它的285个UMCCC成员获得了超过8200万美元的研究资金，其中包括超过3700万美元的研究资金。 每年有1000万美元的NCI直接支持。UMCCC对癌症研究产生了重大影响， 通过在高影响力期刊上发表至少315篇文章证明，将52%的UMCCC干预 累积到制药商发起的试验中，并一直名列前十名的癌症中心 在这段时间内，全国各地都在为NCI提供资金。