Gastrointestinal Oncology
Gastrointestinal Oncology
批准号:
8300280
负责人:
MAX S. WICHA
金额:
$16.91万
依托单位国家:
美国
项目类别:
财政年份:
2012
资助国家:
美国
项目状态:
已结题
起止时间:
2012-06-01 至 2017-05-31
关键词:
Basic ScienceBiologicalBiological MarkersBiological ProductsCancer Center Support GrantCancer PatientCancer-Predisposing GeneCarcinomaCellsCholangiocarcinomaClinicalClinical ResearchColorectal CancerCombined Modality TherapyDevelopmentDiagnosisDisciplineEarly DiagnosisEpidemiologyEvaluationFundingGastrinsGastroenterologyGastrointestinal NeoplasmsGene Expression ProfileGenesGoalsGrantHealthHelicobacter pyloriHepaticHumanImmunotherapyInflammationInterventional radiologyIntestinesInvestigationLiverLiver neoplasmsMalignant neoplasm of gastrointestinal tractMalignant neoplasm of pancreasMedical OncologyMichiganModalityMolecularMutationNeoadjuvant TherapyNeoplasm MetastasisOperative Surgical ProceduresOutcomeOutcomes ResearchPatientsPhenotypePlayPopulationPreventionPrimary carcinoma of the liver cellsRadiationRadiation OncologyRecruitment ActivityResearchResectableRoleSchoolsSignal Transduction PathwayTherapeuticTranslational ResearchUniversitiesUniversity of Michigan Comprehensive Cancer CenterUnresectableanticancer researchbasecancer preventioncell growthclinical carediagnosis evaluationgastrointestinalhealth care qualityimprovedmalignant stomach neoplasmmembermouse modelmultidisciplinarynovelnovel diagnosticsoncologyoncology programpancreatic cancer cellsprogramsstem cell differentiationtranslational studytumortumorigenesis
中文摘要
胃肠道肿瘤学项目是一个综合性的胃肠道肿瘤研究项目,包括基础研究,临床和转化研究。该计划由来自密歇根大学9个不同部门和两所学校的39名成员组成,每年获得900万美元的直接支持,其中包括4.4美元的NCI资金。GI赠款组合包括用于研究结直肠癌和胰腺癌的210万美元SPORE赠款,两项PO1赠款,U01和U19赠款。该计划的重点是发展人类胃肠道癌症的病因和预防的基础基础研究,以及应用这些研究成果的转化研究,以改善胃肠道癌症的早期和准确诊断,评估和治疗方法以及与健康质量结果相关的问题,胃肠道肿瘤学的基础研究主要集中在细胞生长和分化、干细胞和细胞转移的机制。临床研究的重点是新辅助治疗和生物标志物。结果研究的重点是医疗质量问题。在此资助期间招募的九名新项目成员包括Marwan Fakih博士、邹卫平博士、Grace Chen博士、Chandan Kumar博士、Marina Pasca Di Magliano博士、帕特里克胡博士、Gazala Khan博士、西奥多威林博士和John Carethers博士。这个节目被评为
英文摘要
The Gastrointestinal Oncology Program Is a comprehensive program in gastrointestinal cancer research encompassing basic research, clinical and translational research. The program consists of 39 members from 9 different departments and two schools within the University of Michigan, receiving $9 million in annual direct support, Including $4.4 in NCI funding. The GI grant portfolio includes a $2.1 M SPORE grant to study colorectal and pancreatic cancer, two PO1 grants, U01 and U19 grants. The program is focused on the development of fundamental basic research into the causes and prevention of human gastrointestinal cancers and translational studies applying these research findings to improve the early and accurate diagnosis, evaluation, and therapeutic approaches to gastrointestinal cancer as well as Issues related to health quality outcomes, The basic research alms of the Gastrointestinal Oncology Program focus on mechanisms of cell growth and differentiation, stem cells and cell metastasis. The clinical research focuses on neoadjuvant therapies and biomarkers. The outcome research focuses on health care quality Issues. Nine new program members recruited over this grant period include Drs Marwan Fakih, Weiping Zou, Grace Chen, Chandan Kumar, Marina Pasca Di Magliano, Patrick Hu, Gazala Khan, Theodore Welling, and John Carethers. This program, which was rated as
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会议论文
Targeting breast cancer stem cells
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批准号:10331012
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项目类别:
-
资助金额:$91.14万
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财政年份:2016
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负责人:MAX S. WICHA
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依托单位:
Targeting breast cancer stem cells
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批准号:8955932
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项目类别:
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资助金额:$93.0万
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财政年份:2016
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负责人:MAX S. WICHA
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依托单位:
Targeting breast cancer stem cells
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批准号:10093979
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项目类别:
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资助金额:$91.55万
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财政年份:2016
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负责人:MAX S. WICHA
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依托单位:
Cancer Cell Biology
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批准号:8709427
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项目类别:
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资助金额:$7.45万
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财政年份:2013
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负责人:MAX S. WICHA
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依托单位:
Cancer Cell Biology
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批准号:8719610
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项目类别:
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资助金额:$5.0万
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财政年份:2013
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负责人:MAX S. WICHA
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依托单位:
Experimental Therapeutics
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批准号:8300274
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项目类别:
-
资助金额:$54.07万
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财政年份:2012
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负责人:MAX S. WICHA
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依托单位:
Cancer Genetics
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批准号:8300271
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项目类别:
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资助金额:$30.17万
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财政年份:2012
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负责人:MAX S. WICHA
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依托单位:
Flow Cytometry
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批准号:8300287
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项目类别:
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资助金额:$13.98万
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财政年份:2012
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负责人:MAX S. WICHA
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依托单位:
Prostate Oncology
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批准号:8300276
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项目类别:
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资助金额:$36.67万
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财政年份:2012
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负责人:MAX S. WICHA
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依托单位:
High Throughput Screening
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批准号:8300297
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项目类别:
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资助金额:$12.51万
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财政年份:2012
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负责人:MAX S. WICHA
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依托单位:
Biomedical Prevention
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批准号:8300282
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项目类别:
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资助金额:$29.69万
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财政年份:2012
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负责人:MAX S. WICHA
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依托单位:
Immunologic Monitoring
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批准号:8300291
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项目类别:
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资助金额:$19.75万
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财政年份:2012
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负责人:MAX S. WICHA
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依托单位:
Socio-Behavioral
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批准号:8300283
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项目类别:
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资助金额:$14.22万
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财政年份:2012
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负责人:MAX S. WICHA
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依托单位:
Patient and Population Sciences
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批准号:8300285
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项目类别:
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资助金额:$22.91万
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财政年份:2012
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负责人:MAX S. WICHA
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依托单位:
Head and Neck Oncology
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批准号:8300279
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项目类别:
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资助金额:$8.31万
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财政年份:2012
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负责人:MAX S. WICHA
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依托单位:
Molecular Imaging
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批准号:8300273
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项目类别:
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资助金额:$4.96万
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财政年份:2012
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负责人:MAX S. WICHA
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依托单位:
Hematologic Malignancies/BMT
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批准号:8300281
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项目类别:
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资助金额:$49.09万
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财政年份:2012
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负责人:MAX S. WICHA
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依托单位:
Cancer Informatics
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批准号:8300284
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项目类别:
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资助金额:$17.87万
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财政年份:2012
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负责人:MAX S. WICHA
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依托单位:
Pharmacokinetics
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批准号:8300292
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项目类别:
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资助金额:$15.44万
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财政年份:2012
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负责人:MAX S. WICHA
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依托单位:
Tissue and Molecular Pathology
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批准号:8300290
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项目类别:
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资助金额:$14.79万
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财政年份:2012
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负责人:MAX S. WICHA
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依托单位:
海外基金