Gastrointestinal Oncology

胃肠道肿瘤学

• 批准号: 8300280
• 负责人: MAX S. WICHA
• 金额: $ 16.91万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-06-01 至 2017-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8300280
• 关键词: Basic Science; Biological; Biological Markers; Biological Products; Cancer Center Support Grant; Cancer Patient; Cancer-Predisposing Gene; Carcinoma; Cells; Cholangiocarcinoma; Clinical; Clinical Research; Colorectal Cancer; Combined Modality Therapy; Development; Diagnosis; Discipline; Early Diagnosis; Epidemiology; Evaluation; Funding; Gastrins; Gastroenterology; Gastrointestinal Neoplasms; Gene Expression Profile; Genes; Goals; Grant; Health; Helicobacter pylori; Hepatic; Human; Immunotherapy; Inflammation; Interventional radiology; Intestines; Investigation; Liver; Liver neoplasms; Malignant neoplasm of gastrointestinal tract; Malignant neoplasm of pancreas; Medical Oncology; Michigan; Modality; Molecular; Mutation; Neoadjuvant Therapy; Neoplasm Metastasis; Operative Surgical Procedures; Outcome; Outcomes Research; Patients; Phenotype; Play; Population; Prevention; Primary carcinoma of the liver cells; Radiation; Radiation Oncology; Recruitment Activity; Research; Resectable; Role; Schools; Signal Transduction Pathway; Therapeutic; Translational Research; Universities; University of Michigan Comprehensive Cancer Center; Unresectable; anticancer research; base; cancer prevention; cell growth; clinical care; diagnosis evaluation; gastrointestinal; health care quality; improved; malignant stomach neoplasm; member; mouse model; multidisciplinary; novel; novel diagnostics; oncology; oncology program; pancreatic cancer cells; programs; stem cell differentiation; translational study; tumor; tumorigenesis

The Gastrointestinal Oncology Program Is a comprehensive program in gastrointestinal cancer research encompassing basic research, clinical and translational research. The program consists of 39 members from 9 different departments and two schools within the University of Michigan, receiving $9 million in annual direct support, Including $4.4 in NCI funding. The GI grant portfolio includes a $2.1 M SPORE grant to study colorectal and pancreatic cancer, two PO1 grants, U01 and U19 grants. The program is focused on the development of fundamental basic research into the causes and prevention of human gastrointestinal cancers and translational studies applying these research findings to improve the early and accurate diagnosis, evaluation, and therapeutic approaches to gastrointestinal cancer as well as Issues related to health quality outcomes, The basic research alms of the Gastrointestinal Oncology Program focus on mechanisms of cell growth and differentiation, stem cells and cell metastasis. The clinical research focuses on neoadjuvant therapies and biomarkers. The outcome research focuses on health care quality Issues. Nine new program members recruited over this grant period include Drs Marwan Fakih, Weiping Zou, Grace Chen, Chandan Kumar, Marina Pasca Di Magliano, Patrick Hu, Gazala Khan, Theodore Welling, and John Carethers. This program, which was rated as

胃肠肿瘤学项目是胃肠道癌症研究的综合项目，包括基础研究、临床和转化研究。该计划由来自密歇根大学 9 个不同院系和两所学院的 39 名成员组成，每年获得 900 万美元的直接支持，其中包括 4.4 美元的 NCI 资助。 GI 拨款组合包括用于研究结直肠癌和胰腺癌的 210 万美元 SPORE 拨款、两项 PO1 拨款、U01 和 U19 拨款。该项目的重点是开展人类胃肠道癌症的病因和预防的基础研究，以及应用这些研究成果的转化研究，以改进胃肠道癌症的早期准确诊断、评估和治疗方法以及与健康质量结果相关的问题。胃肠道肿瘤学项目的基础研究重点是细胞生长和分化、干细胞和细胞转移的机制。临床研究重点是新辅助疗法和生物标志物。结果研究的重点是医疗保健质量问题。在此资助期内招募的九名新项目成员包括 Marwan Fakih 博士、Weiping Zou、Grace Chen、Chandan Kumar、Marina Pasca Di Magliano、Patrick Hu、Gazala Khan、Theodore Welling 和 John Carethers。该节目被评为