Biomedical Prevention

生物医学预防计划有来自16个部门和4所学校的41名研究人员，研究基础每年直接资助680万美元，其中包括来自NCI的440万美元。它的成员在这段时间里发表了1092篇论文，其中37%是计划内合作，39%是计划间合作。这些出版物中有155篇发表在影响力较大的期刊上(影响因子7.51)。生物医学预防计划的目标是通过早期诊断预防癌症的发生，提高生存率，从而降低癌症的发病率和死亡率。该计划的资金来源是：1)建立和支持包含环境和遗传方法的以器官为重点的垂直整合研究项目，以确定未来肿瘤进展的高风险个人和人群；2)通过整合高通量基因组、蛋白质组和生物技术，发现和验证用于风险评估和常见、高死亡率癌症早期检测的生物标记物；3)确定和确定使用药理和营养工具的干预措施的预防效果，目的是延缓或逆转被确定为高危个体的肿瘤进展；以及4)开发和验证新的生物统计方法，以研究人口集群和代理终点。这些方案的目标人群包括普通人群和特殊高危群体。

The Biomedical Prevention Program has 41 investigators from 16 departments and four schools with a research base of $6.8 million in annual direct funding, Including $4.4 million from the NCI. Its members published 1092 papers over this grant period, of which 37% were intra-programmatic and 39% ware interprogrammatic collaborations. 155 of these publications were in high impact journals (Impact factor > 7.51). The objective of the Biomedical Prevention Program is to reduce the morbidity and mortality caused by cancer through preventing the occurrence and improving survival with earlier diagnosis. The alms of the program are: 1) To build and to support organ-focused, vertically Integrated research projects that encompass environmental and genetic approaches In order to Identify individuals and populations a high risk for future neoplastic progression; 2) To discover and validate biomarkers for risk assessment and early detection of common, high mortality cancers through the integration of high throughput genomic, proteomic, and biotechnologies; 3) To Identify and determine preventive efficacy of Interventions with pharmacologic and nutritional tools with the aim of delaying or reversing neoplastic progression in individuals identified at high risk; and 4) To develop and validate new biostatistical methodologies to study population clusters and surrogate endpoints. The populations targeted for these programs include the general population and special at-risk groups.