Cancer Cell Biology

癌细胞生物学(CCB)计划由来自23个部门的62名成员组成。自上一个资助周期以来，癌症细胞生物学的研究基数几乎翻了一番，从15,046,494美元增加到22,406,120美元，每年直接研究资助总额为22,406,120美元，其中3,643,399美元来自国家癌症研究所。在上一次的资助期间，有558份癌症细胞生物学计划成员的出版物，其中3.9%是计划内的，24.2%是计划间的。 癌症细胞生物学计划的成员是国家公认的学科范围内的专家，统一的目标是在细胞和分子水平上加深我们对肿瘤形成过程的理解，以便开发治疗和预防癌症的新策略。项目研究人员在非调控的生长、增殖和细胞死亡途径领域拥有先进的癌症生物学：染色质重塑；癌症干细胞；胚胎信号通路；以及肿瘤侵袭程序。由我们的计划成员进行的基于实验台的研究已经导致了使用新的、有针对性的癌症治疗方法的转化性研究和临床试验，这可能会比目前可用的治疗方法提供显著的优势。

The Cancer Cell Biology (CCB) Program is comprised of 62 members from 23 departments. Since the past funding cycle the research base of the Cancer Cell Biology has nearly doubled from $15,046,494 to $22,406,120 total annual direct research support, of which $3,643,399 is from the NCI. Over this last grant period, there were 558 publications of Cancer Cell Biology Program members, of which 3.9% are intraprogrammatic and 24.2% are inter-programmatic . Members of the Cancer Cell Biology program are nationally recognized experts in a spectrum of disciplines unified by the goal of furthering our understanding of the process of oncogenesis at the cellular and molecular level, In order to develop new strategies for the treatment and prevention of cancer. Program investigators have advanced cancer biology in the areas of deregulated growth, proliferation, and cell death pathways: chromatin remodeling; cancer stem cells; embryonic signaling pathways; and tumor invasion programs. The bench-based research carried out by our program members has led to translational studies and clinical trials using novel, targeted approaches to cancer therapy which may afford significant advantages over currently available therapeutics.