Cancer Cell Biology

癌细胞生物学

• 批准号: 8709427
• 负责人: MAX S. WICHA
• 金额: $ 7.45万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-06-01 至 2017-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8709427
• 关键词: Advanced Malignant Neoplasm; Antibodies; Area; Basal cell carcinoma; Breast; Cancer Biology; Cancer Center Support Grant; Cell Death; Cellular biology; Clinical Trials; Colorectal Cancer; Data; Development; Discipline; Embryo; Erinaceidae; Funding; Future; Goals; Grant; Growth; Human; MMP14 gene; MT2-MMP; Maintenance; Malignant Neoplasms; Malignant neoplasm of ovary; Matrix Metalloproteinases; Mission; Molecular; Multiple Myeloma; Neoplasm Metastasis; Neoplasms; Pancreas; Pancreatic Adenocarcinoma; Pathway interactions; Peptide Hydrolases; Phase; Phase I Clinical Trials; Process; Publications; Publishing; Research; Research Personnel; Research Support; Scientist; Signal Pathway; Soft Tissue Neoplasms; Solid Neoplasm; Staging; Testing; Therapeutic; Tumor Biology; Tumor Cell Invasion; University of Michigan Comprehensive Cancer Center; Work; base; cancer cell; cancer prevention; cancer stem cell; cancer therapy; cancer type; chromatin remodeling; docetaxel; gamma secretase; gemcitabine; improved; inhibitor/antagonist; malignant breast neoplasm; member; neutralizing antibody; novel; preclinical study; programs; smoothened signaling pathway; translational study; treatment effect; treatment strategy; trial comparing; tumor; tumorigenesis

The Cancer Cell Biology (CCB) Program is comprised of 62 members from 23 departments. Since the past funding cycle the research base of the Cancer Cell Biology has nearly doubled from $15,046,494 to $22,406,120 total annual direct research support, of which $3,643,399 is from the NCI. Over this last grant period, there were 558 publications of Cancer Cell Biology Program members, of which 3.9% are intraprogrammatic and 24.2% are inter-programmatic . Members of the Cancer Cell Biology program are nationally recognized experts in a spectrum of disciplines unified by the goal of furthering our understanding of the process of oncogenesis at the cellular and molecular level, In order to develop new strategies for the treatment and prevention of cancer. Program investigators have advanced cancer biology in the areas of deregulated growth, proliferation, and cell death pathways: chromatin remodeling; cancer stem cells; embryonic signaling pathways; and tumor invasion programs. The bench-based research carried out by our program members has led to translational studies and clinical trials using novel, targeted approaches to cancer therapy which may afford significant advantages over currently available therapeutics.

癌症细胞生物学（CCB）计划由来自23个部门的62名成员组成。自上一个资助周期以来，癌症细胞生物学的研究基础几乎翻了一番，从15，046，494美元增加到22，406，120美元，其中3，643，399美元来自NCI。在上一个资助期内，癌症细胞生物学项目成员发表了558篇论文，其中3.9%是项目内的，24.2%是项目间的。 癌症细胞生物学计划的成员是国家认可的专家，他们在一系列学科中统一了我们在细胞和分子水平上进一步了解肿瘤发生过程的目标，以开发治疗和预防癌症的新策略。项目研究人员在生长、增殖和细胞死亡途径失调领域推进了癌症生物学：染色质重塑;癌症干细胞;胚胎信号传导途径;和肿瘤侵袭计划。我们的项目成员进行的基于实验室的研究已经导致了转化研究和临床试验，这些研究和临床试验使用了新型的、有针对性的癌症治疗方法，这些方法可能比当前可用的治疗方法具有显着的优势。