Patient and Population Sciences

密歇根大学综合癌症中心(UMCCC)是美国首屈一指的多学科癌症研究项目之一，在患者和基于人群的研究方面有着悠久的卓越机构传统。患者和人口核心是根据UMCCC的战略规划开发的一种新的癌症中心核心资源，以满足通过战略规划过程确定的癌症中心研究人员的关键需求。癌症预防和控制、临床研究和基础科学方面的项目都需要加强对带有DNA样本的注释患者和人群数据的访问，以继续癌症中心在个性化癌症预防、诊断和治疗方面实现创新研究的使命和承诺。Patient and Popular Core是一个收集、编目和存储DNA样本的资源，以及来自癌症患者和有代表性的非癌症对照的高度注释、链接的临床和流行病学信息。在已经建立的癌症中心基础设施和卫生系统范围内对生物库的机构承诺的基础上，患者和人口核心利用密歇根临床健康研究所(MICHR)生物资源库和密歇根临床研究单位(MCRU)的联合资源向癌症中心成员提供针对癌症的资源，这些资源将促进癌症中心内不同学科的研究人员进行环境、易感性、预后和机制研究，并通过将标本数据与问卷和医疗记录数据联系起来，为试验性研究和成功提交翻译和分子流行病学研究的拨款提供机会。这一核心的总体目标是进一步增强我们的研究人员的能力，促进资源共享，并为研究参与者、研究人员、UMCCC成员和我们的资助机构最大限度地发挥数据和DNA样本收集的价值。自2010年4月成立以来，患者和人群核心存储库中已建立了3910名患者的DNA样本和数据，7名癌症中心成员访问了DNA样本和数据。CCSG的资金占拟议核心预算的36%，其余的支持来自按机构范围指标和其他机构支持确定的费率的按存储容量使用计费。

The University of Michigan Comprehensive Cancer Center (UMCCC) is one of the nation's premiere multidisciplinary cancer research programs, with a long Institutional tradition of excellence in patient and population-based research. The Patient and Population Core is a new cancer center core resource that has been developed as a result of UMCCC's strategic planning to meet key needs of cancer center researchers identified through a strategic planning process. Programs in cancer prevention and control, clinical research, and basic science all require enhanced access to annotated patient and population data with accompanying DNA samples In order to continue the cancer center's mission and commitment to achieve innovative research in personalized cancer prevention, diagnosis and treatment. The Patient and Population Core is a resource that collects, catalogs, and stores DNA samples together with highly annotated, linked clinical and epidemiologic Information from cancer patients and representative controls without cancer. Building upon an already established cancer center infrastructure and health-system wide institutional commitment to biobanking, the Patient and Population Core takes advantage of the combined resources of the Michigan Institute for Clinical Health Research (MICHR) Biorepository and the Michigan Clinical Research Unit (MCRU) to provide cancer-specific resources to members of the cancer center, This resource will facilitate environmental, susceptibility, prognostic, and mechanistic studies to be conducted by researchers from various disciplines within the cancer center, as well as provide opportunities for pilot studies and resources for successful grant submissions for translational and molecular epidemiologic research studies, by linking specimen data with questionnaire and medical record data. The overall goal of this core is to further empower our investigators, promote resource sharing, and maximize the value of data and DNA sample collection for research participants, investigators, UMCCC members, and our funding agencies. Since its inception in April 2010, DNA samples and data from 3,910 patients have been established within the Patient and Population Core repository, and 7 cancer center members have accessed DNA samples and data. CCSG funding comprises 36% of the proposed core budget, with the remaining support from charge-backs at rates determined by institution-wide metrics and other institutional support.