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Cancer Genetics

癌症遗传学

基本信息

批准号：
8300271
负责人：
MAX S. WICHA
金额：
$ 30.17万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-06-01 至 2017-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8300271
关键词：
Acetylation Acute Lymphocytic Leukemia Adrenal Gland Cancer Appointment BRCA1 gene Base Excision Repairs Base Sequence Basic Science Beer Belief Bioinformatics Biological Assay Biometry Breast CDX2 gene Cancer Center Support Grant Cancer Patient Cellular biology Chromatin Chromosome Fragile Sites Clinical Management Clinical Sciences Collaborations Colon Colon Carcinoma Colonic Neoplasms Commit Complex DNA Damage DNA Repair Defect Development EZH2 gene Enhancers Epigenetic Process Erinaceidae Faculty Family Funding Gene Expression Gene Expression Profile Gene Expression Regulation Gene Fusion Gene Mutation Gene Silencing Genes Genetic Genetic Programming Genetic Transcription Genetically Engineered Mouse Genome Genome Stability Genomic Instability Genomics Germ Lines Glioblastoma Goals Gonadal Steroid Hormones Grant Head and neck structure Human Interdisciplinary Study Knock-out Knockout Mice Knowledge Laboratory Research Lead Lymphoma MAP Kinase Gene Malignant Neoplasms Malignant neoplasm of cervix uteri Malignant neoplasm of esophagus Malignant neoplasm of lung Malignant neoplasm of ovary Malignant neoplasm of prostate Malignant neoplasm of thyroid Mentors Methodology Methods Methyltransferase Modeling Molecular Molecular Analysis Mutation Nature Neoplasm Metastasis Neurofibromatoses Nonhomologous DNA End Joining Normal Cell Nuclear Protein Pathogenesis Pathway interactions Population Sciences Prevention Process Prostate Proteins Proteomics Publications Radiation Records Recurrence Regulation Research Research Personnel Retrotransposition Robin bird Role Schools Science Screening for cancer Somatic Cell Somatic Mutation Steroid Receptors Study models System Technology Therapeutic Therapeutic Intervention Tissues Transcriptional Regulation Transgenic Mice Transgenic Organisms Translational Research Tumor Suppressor Genes University of Michigan Comprehensive Cancer Center Variant Viral artemis base beta catenin cancer cell cancer genetics chromatin modification college gene repression genetic analysis histone acetyltransferase improved malignant breast neoplasm melanoma member mouse model nerve stem cell notch protein novel diagnostics oncology outcome forecast ovarian neoplasm professor programs protein function receptor function repaired response stem cell fate trait transcription factor tumorigenesis

项目摘要

The Cancer Genetics Program (CGP) is an interdisciplinary research group of 37 investigators from 13 departments and three different schools/colleges, Since the past funding cycle, tine research base of the Cancer Genetics Program has increased 180% from $3,866,370 to $10,978,820 total annual direct support, of which $1,132,859 is from the NCI. Over this last grant period, there were 472 publications of Cancer Genetics Program members, of which 8.4% are intra-programmatic and 31.9% are Inter-programmatic. The CGP pursues laboratory and translational research, emphasizing genetic and genomics approaches, with the overarching goal of advancing knowledge of the nature and role of mutations and gene expression changes In the development and altered phenotypic traits of cancer. Investigatory in the CGP are committed to the pursuit of research that will not only inform understanding of the origins and nature of cancer but that will also lead to novel diagnostic approaches for cancer and improved clinical management of cancer patients. Investigators in the Program collaborate with investigators in other University of Michigan Comprehensive Cancer Center (UMCCC) programs in the Basic Science, Clinical Science and Population Sciences Divisions, including Cancer Cell Biology, Radiation Sciences, Experimental Therapeutics, Breast Oncology, GI Oncology, Prostate Oncology, and Biomedical Prevention. The CGP has four major research themes: I) Defining oncogene and tumor suppressor gene network defects and gene expression signatures in cancers of various types. II) Characterization of mechanisms of gene regulation by transcription factor complexes and chromatin modification factors in cancer cells. III) Elucidation of genetic and epigenetic mechanisms contributing to genomic instability in cancer. IV) Development of genetically engineered mouse models for investigating the role of recurrent gene defects in cancer pathogenesis.

癌症遗传学计划（CGP）是一个跨学科的研究小组，由来自13个部门和三个不同的学校/学院的37名研究人员组成，自上一个资助周期以来，癌症遗传学计划的研究基础已经从3，866，370美元增加到10，978，820美元，其中1，132，859美元来自NCI。在上一个资助期内，癌症遗传学项目成员发表了472篇论文，其中8.4%是项目内的，31.9%是项目间的。CGP追求实验室和转化研究，强调遗传和基因组学方法，其总体目标是推进对突变和基因表达变化在癌症发展和改变表型特征中的性质和作用的认识。CGP的研究致力于研究，不仅有助于了解癌症的起源和性质，而且还将导致癌症的新诊断方法和改善癌症患者的临床管理。该计划的研究人员与密歇根大学综合癌症中心（UMCCC）基础科学，临床科学和人口科学部门的其他计划的研究人员合作，包括癌细胞生物学，放射科学，实验治疗学，乳腺肿瘤学，GI肿瘤学，前列腺肿瘤学和生物医学预防。CGP有四个主要研究主题： I）定义各种类型癌症中的癌基因和肿瘤抑制基因网络缺陷和基因表达特征。 II）癌细胞中转录因子复合物和染色质修饰因子的基因调控机制的表征。 III）阐明导致癌症中基因组不稳定性的遗传和表观遗传机制。 IV）开发用于研究复发性基因缺陷在癌症发病机制中的作用的基因工程小鼠模型。