HISTOLOGY

组织学和免疫组织化学 组织学和免疫组织化学资源对于提供必要的形态学数据至关重要 在将切除的组织用于不同的分析测定之前， 因此，组织的组织学检查确定不存在异常病理，例如 炎症、坏死、出血或肿瘤，然后在各种实验中使用组织提取物。 对特定基因在癌症中的作用的科学研究通常依赖于以下能力： 翻译从酶联免疫吸附测定、聚合酶 链反应或甚至北方，南方，西方印迹，以确定表达的细胞类型， 组织切片。通过流式细胞术分析单细胞，或使用共聚焦显微镜分析组织切片， 通过使用确认的组织学方法来促进显微镜检查。很多时候，这是表达 特定组织中的基因产物，使研究人员能够推断其存在的意义， 它的功能。从组织分析中获得的结果在规划未来的发展方向方面也是至关重要的。 项目 这种流行资源的最低充电率也允许癌症中心成员检查 从各种癌症小鼠模型中获得的组织。虽然小鼠的组织病理学与人类相似， 在组织病理学上，存在许多差异，这可能会混淆准确的解释。因此 随时提供与资源领导人，一名委员会认证的病理学家，经验丰富的 解释人类疾病的小鼠模型，是这一资源的重要资产。

Histology and Immunohistochemistry The Histology and Immunohistochemistry Resource is crucial for providing the prerequisite morphologic data on any sample of organ or tissue, prior to the use of the excised tissue in different analytical assays. Histological examination of tissue thus establishes the absence of abnormal pathology, such as inflammation, necrosis, hemorrhage or tumor, prior to using the extracts of the tissue in various experiments. Scientific investigation of the role of particular genes in cancer is very often dependent on the ability to translate observations obtained from methods such as enzyme linked immunosorbent assays, polymerase chain reaction or even Northern, Southern, Western blots, into identifying the cell types of expression in tissue sections. The analysis of single cells by flow cytometry, or the analysis of tissue sections with confocal microscopy is facilitated by the use of confirmatory histological methods. Very often, it is the expression of gene products in a particular tissue that allows the investigator to deduce the significance of its presence to its function. The results obtained from analysis of tissue are also critical in the planning of future directions of projects. The minimal recharge rates of this popular resource also permits Cancer Center members to examine tissues obtained from various mouse models of cancer. Although mouse histopathology is similar to human histopathology, there are numerous differences, which can confound accurate interpretation. Thus the readily available dne-on-one consultation with the resource leader, a board certified pathologist, experienced with interpretation of mouse models of human disease, is a critical asset of this resource.