Impact of host iron status on growth and viability of erythrocytic stages of Plas

宿主铁状态对 Plas 红细胞阶段生长和活力的影响

• 批准号: 7917467
• 负责人: Carla Cerami
• 金额: $ 20.06万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-20 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7917467
• 关键词: Affect; Age; Area; Biological Assay; Biological Availability; Cessation of life; Chelating Agents; Child; Clinical Trials; Country; Development; Developmental Delay Disorders; Erythrocytes; Folic Acid; Growth; Growth and Development function; Healthcare; Human; Hypoxanthines; Immune response; Immune system; In Vitro; Individual; Infection; Invaded; Iron; Iron Chelating Agents; Iron deficiency anemia; Malaria; Morbidity - disease rate; Mus; Nutrient; Organism; Parasitemia; Parasites; Patients; Pemba; Perinatal mortality demographics; Placenta; Plague; Plasmodium falciparum; Policies; Pregnancy; Pregnant Women; Preschool Child; Publishing; Regulation; Risk; Serum; Staging; Supplementation; Woman; Zanzibar; base; cytotoxic; evidence base; in vivo; micronutrient deficiency; parasite invasion; programs; public health relevance; response; transmission process

DESCRIPTION (provided by applicant): Iron deficiency is one of the most common micronutrient deficiencies in the world in pregnant women and children and it causes increased risk of perinatal mortality, morbidity and developmental delay. Recent evidence has suggested that iron deficiency may protect against malaria. Thus, the wisdom of universal supplementation in areas of the world where malaria is endemic has come under scrutiny. This application will attempt to identify the mechanism by which the human host's iron status affects the P. falciparum parasite in vitro. Specifically, we will determine if the growth, maturation and invasion rate of P. falciparum parasites is reduced in red blood cells and/or serum from severely iron deficient individuals before and after iron supplementation. The results will contribute to efforts to develop evidence-based iron supplementation policies in malaria-endemic areas. PUBLIC HEALTH RELEVANCE: Iron deficiency affects over 500 million people including many pregnant women and children from areas of the world that are plagued by malaria. It has been suggested that iron deficiency protects against malaria and questions have been raised about the risks associated with the universal iron supplementation programs in countries where malaria is endemic. In the proposed project, we will determine whether the growth and development of the malaria parasite is impacted by the host iron status in vitro. We will use RBC and sera from patients with severe iron deficiency anemia to look at this question in a very systematic way. This study will provide information for or against a possible mechanism by which iron deficiency may affect the malaria parasite. Ultimately, this information will provide additional evidence for the determination of policy on iron supplementation in malaria endemic regions.

描述（由申请人提供）：缺铁是世界上孕妇和儿童最常见的微量营养素缺乏症之一，它会导致围产期死亡率、发病率和发育迟缓的风险增加。最近的证据表明，缺铁可以预防疟疾。因此，在世界疟疾流行地区普及补充剂的明智之举受到了审查。本申请将试图确定人体宿主的铁状态在体外影响恶性疟原虫的机制。具体而言，我们将确定在铁补充前后，恶性疟原虫寄生虫在严重缺铁个体的红细胞和/或血清中的生长、成熟和侵袭率是否降低。研究结果将有助于在疟疾流行地区制定循证补铁政策。 公共卫生相关性：缺铁影响着5亿多人，包括许多来自世界上疟疾肆虐地区的孕妇和儿童。有人建议，缺铁可以预防疟疾，并提出了与疟疾流行国家的普遍补铁计划相关的风险问题。在本研究中，我们将在体外研究疟原虫的生长和发育是否受到宿主铁状态的影响。我们将使用严重缺铁性贫血患者的红细胞和血清，以非常系统的方式来研究这个问题。这项研究将提供支持或反对铁缺乏可能影响疟原虫的可能机制的信息。最终，这些信息将为疟疾流行地区铁补充政策的确定提供额外的证据。