Impact of host iron status on growth and viability of erythrocytic stages of Plas

描述（由申请人提供）：缺铁是世界上孕妇和儿童最常见的微量营养素缺乏症之一，它会导致围产期死亡率、发病率和发育迟缓的风险增加。最近的证据表明缺铁可以预防疟疾。因此，在世界上疟疾流行地区普遍补充营养是否明智受到了审查。本应用程序将试图确定人类宿主铁状态影响体外恶性疟原虫的机制。具体来说，我们将确定补铁前后严重缺铁个体红细胞和/或血清中恶性疟原虫的生长、成熟和侵袭率是否降低。研究结果将有助于在疟疾流行地区制定循证补铁政策。

DESCRIPTION (provided by applicant): Iron deficiency is one of the most common micronutrient deficiencies in the world in pregnant women and children and it causes increased risk of perinatal mortality, morbidity and developmental delay. Recent evidence has suggested that iron deficiency may protect against malaria. Thus, the wisdom of universal supplementation in areas of the world where malaria is endemic has come under scrutiny. This application will attempt to identify the mechanism by which the human host's iron status affects the P. falciparum parasite in vitro. Specifically, we will determine if the growth, maturation and invasion rate of P. falciparum parasites is reduced in red blood cells and/or serum from severely iron deficient individuals before and after iron supplementation. The results will contribute to efforts to develop evidence-based iron supplementation policies in malaria-endemic areas. PUBLIC HEALTH RELEVANCE: Iron deficiency affects over 500 million people including many pregnant women and children from areas of the world that are plagued by malaria. It has been suggested that iron deficiency protects against malaria and questions have been raised about the risks associated with the universal iron supplementation programs in countries where malaria is endemic. In the proposed project, we will determine whether the growth and development of the malaria parasite is impacted by the host iron status in vitro. We will use RBC and sera from patients with severe iron deficiency anemia to look at this question in a very systematic way. This study will provide information for or against a possible mechanism by which iron deficiency may affect the malaria parasite. Ultimately, this information will provide additional evidence for the determination of policy on iron supplementation in malaria endemic regions.