TESTOSTERONE AND GROWTH HORMONE IMPROVE BODY COMPOSITION AND

睾酮和生长激素改善身体成分

• 批准号: 7954033
• 负责人: FRED R SATTLER
• 金额: $ 0.35万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-02-01 至 2010-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7954033
• 关键词: Adult; Age-Years; Aging; Body Composition; Body fat; Communities; Computer Retrieval of Information on Scientific Projects Database; Enrollment; Funding; Grant; Impairment; Institution; Insulin-Like Growth Factor I; Intervention; Investigation; Leuprolide Acetate; Masks; Mass Spectrum Analysis; Muscle function; Physiological; Randomized; Research; Research Personnel; Resources; Somatotropin; Source; Supplementation; Testing; Testosterone; United States; United States National Institutes of Health; Universities; biomedical resource; improved; men; muscle form; older men; pituitary gonadal axis

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. With aging, impairments in the pituitary-gonadal axis are associated with loss of muscle mass and function and accumulation of upper body fat. We tested the hypothesis that physiologic supplementation with testosterone and growth hormone together improves body composition and muscle function in 65-90 year-old men with low testosterone and IGF-1 levels. This was a factorial (2X3) two tiered, randomized, double masked investigation conducted at three university research centers located in the western, central and eastern United States. We enrolled 122 community dwelling men 70.8¿4.2 years-of-age with BMI=27.4¿3.4kg/m2, testosterone d19.1nmol/L (550ng/dL) and IGF-1 in lower adult tertile (d21.9nmol/L=167ng/dL). The interventions included transdermal testosterone (5g or 10g/day) during suppression of endogenous testosterone with leuprolide acetate (7.5mg/monthly) and growth hormone (0, 3, or 5ug/kg/day) for 16 weeks.

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