DURABILITY OF THE EFFECTS OF TESTOSTERONE AND GROWTH HORMONE SUPPLEMENTATION

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 目的：确定老年男性停止睾酮和生长激素补充后合成代谢作用和不良事件（AE）的持久性。设计图：双盲、随机对照试验（2X 3析因设计），测试睾酮凝胶（5g或10 g/天）和rhGH（0、3或5 ug/kg/天），持续16周，3个月后随访。参与者：108名居住在社区的65-90岁男性。测量值：睾酮和IGF-1水平、身体组成（DEXA）、1次重复最大（1-RM）力量、爬楼梯能力、生活质量（QOL）和活动问卷、AE。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Objectives: Determine the durability of anabolic effects and adverse events (AEs) after stopping testosterone and growth hormone supplementation in older men. Design: Double-masked, randomized controlled trial (2X3 factorial design) to test testosterone gel (5g or 10g/daily) and rhGH (0, 3, or 5ug/kg/day) for 16-weeks with follow-up 3-months later. Participants: 108 community-dwelling 65-90 year-old-men. Measurements: Testosterone and IGF-1 levels, body composition (DEXA), 1-repetition maximum (1-RM) strength, stair-climbing power, quality-of-life (QOL) and activity questionnaires, AEs.