HORMONAL REGULATORS OF MUSCLE AND METABOLISM IN AGING (HORMA)--1 R01 AG18169-01

衰老过程中肌肉和新陈代谢的激素调节剂 (HORMA)--1 R01 AG18169-01

• 批准号: 7716680
• 负责人: FRED R SATTLER
• 金额: $ 28.84万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-20 至 2008-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7716680
• 关键词: Activities of Daily Living; Age; Aging; Aging-Related Process; Androgens; Computer Retrieval of Information on Scientific Projects Database; Elderly; Fiber; Funding; Future; Grant; Hormonal; Hormones; Institution; Moods; Muscle; Musculoskeletal; Persons; Proteins; Quality of life; Relative (related person); Research; Research Personnel; Resources; Skeletal Muscle; Somatotropin; Source; System; Testing; Testosterone; United States National Institutes of Health; experience; frailty; gonad function; hormone deficiency; muscle metabolism; muscle strength; novel; sarcopenia

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Elderly persons experience progressive loss of skeletal muscle mass, muscle strength, functional capacity for activities of daily living, have impaired mood, and eventually lose independence. Aging is also associated with a loss of gonadal function and integrity of the growth hormone (GH/IGF-laxis. However, the relationship of deficiencies of these hormones axes to sarcopenia and frailty in aging has not been established or whether there is an interactions of these two hormone systems in maintaining normal muscle mass and function. We hypothesize that both hormone systems regulate musculoskeletal protein mass and contractile fibers by different and complimentary mechanisms and that optimal levels of both testosterone and GH/IGF-1 are necessary to maintain skeletal muscle mass, muscular strength, full functional activities of daily living, quality of life, and independence during the aging process. The findings of this study should result in important mechanistic understanding of the relative contributions of androgen deficiency and hyposomatotropism in elderly persons with frailty related to decreased muscle mass and strength. The results should also provide valuable information for future testing of new, novel treatment strategies which are more tolerable and convenient than parenteral therapies in age associated sarcopenia with frailty.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 老年人的骨骼肌质量、肌肉力量、日常生活活动功能逐渐丧失，情绪受损，最终失去独立性。 衰老还与性腺功能和生长激素完整性的丧失（GH/IGF-松弛）有关。然而，这些激素轴的缺乏与肌肉减少症和衰老虚弱之间的关系尚未确定，也尚未确定这两种激素系统在​​维持正常肌肉质量和功能方面是否存在相互作用。我们假设这两种激素系统都调节肌肉骨骼蛋白质量和收缩力 睾酮和 GH/IGF-1 的最佳水平对于维持骨骼肌质量、肌肉力量、日常生活的全部功能活动、生活质量和衰老过程中的独立性是必要的。 这项研究的结果应该有助于人们对因肌肉质量和力量下降而导致虚弱的老年人中雄激素缺乏和体质低下的相对影响产生重要的机制理解。的 结果还应该为未来测试新的、新颖的治疗策略提供有价值的信息，这些策略比胃肠外治疗在年龄相关的肌少症伴虚弱方面更耐受和方便。