EVALUATION OF HIGH-PROTEIN SUPPLEMENTATION IN WEIGHT-STABLE HIV-POSITIVE

体重稳定的 HIV 阳性患者的高蛋白补充评估

基本信息

  • 批准号:
    8168764
  • 负责人:
  • 金额:
    $ 1.23万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2010
  • 资助国家:
    美国
  • 起止时间:
    2010-03-10 至 2010-12-31
  • 项目状态:
    已结题

项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. HIV patients with wasting are at increased risk of opportunistic complications and fatality. We hypothesized that augmenting dietary intake with high-biologic-value protein would enhance weight and lean tissue in weight-stable subjects with a prior unintentional weight loss of >3%. Fifty-nine subjects with HIV RNA concentrations <5000 copies/mL were randomly assigned to receive a 280-kcal supplement containing 40 g whey protein or a matched isocaloric control supplement without added protein twice daily for 12 wk. Before the study, intake of total energy and protein exceeded estimated requirements (44.3 ¿ 12.6 kcal/kg/d and 1.69 ¿ 0.55 g/kg/d, respectively). Both supplements failed to increase total energy intake because of decreases in self-selected food intake. Changes in weight (0.8 ¿ 2.4 and 0.7 ¿ 2.4 kg) and lean body mass (0.3 ¿ 1.4 and 0.3 ¿ 1.5 kg) did not differ significantly between the whey protein and control groups, respectively. Waist-to-hip ratio improved more with whey protein (-0.02 ¿ 0.05) than in control (0.01 ¿ 0.03; P=0.025) at week 6 but not at week 12. Fasting triacylglycerol increased by 39 ¿ 98 mg/dL with the control supplement and decreased by 16 ¿ 62 mg/dL with whey protein at week 12 (P=0.03). CD4 lymphocytes increased by 31 ¿ 84 cells/mm3 with whey protein and decreased by 5 ¿ 124 cells/mm3 with the control supplement at 12 wk (P=0.03). Gastrointestinal symptoms occurred more often with whey protein.
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项目成果

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FRED R SATTLER其他文献

FRED R SATTLER的其他文献

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{{ truncateString('FRED R SATTLER', 18)}}的其他基金

DURABILITY OF THE EFFECTS OF TESTOSTERONE AND GROWTH HORMONE SUPPLEMENTATION
睾酮和生长激素补充剂效果的持久性
  • 批准号:
    8361472
  • 财政年份:
    2011
  • 资助金额:
    $ 1.23万
  • 项目类别:
TESTOSTERONE THRESHOLD LEVELS AND LEAN TISSUE MASS TARGETS NEEDED
所需的睾酮阈值水平和瘦肉组织质量目标
  • 批准号:
    8361473
  • 财政年份:
    2011
  • 资助金额:
    $ 1.23万
  • 项目类别:
TESTOSTERONE AND GROWTH HORMONE IMPROVE BODY COMPOSITION AND
睾酮和生长激素改善身体成分
  • 批准号:
    8361388
  • 财政年份:
    2011
  • 资助金额:
    $ 1.23万
  • 项目类别:
WHOLE BODY AND MUSCLE PROTEIN METABOLISM ARE NOT AFFECTED BY ACUTE DEVIATIONS
全身和肌肉蛋白质代谢不受急性偏差的影响
  • 批准号:
    8361467
  • 财政年份:
    2011
  • 资助金额:
    $ 1.23万
  • 项目类别:
TESTOSTERONE AND GROWTH HORMONE IMPROVE BODY COMPOSITION AND
睾酮和生长激素改善身体成分
  • 批准号:
    8168784
  • 财政年份:
    2010
  • 资助金额:
    $ 1.23万
  • 项目类别:
EVALUATION OF HIGH-PROTEIN SUPPLEMENTATION IN WEIGHT-STABLE HIV-POSITIVE
体重稳定的 HIV 阳性患者的高蛋白补充评估
  • 批准号:
    7954017
  • 财政年份:
    2009
  • 资助金额:
    $ 1.23万
  • 项目类别:
TESTOSTERONE AND GROWTH HORMONE IMPROVE BODY COMPOSITION AND
睾酮和生长激素改善身体成分
  • 批准号:
    7954033
  • 财政年份:
    2009
  • 资助金额:
    $ 1.23万
  • 项目类别:
INVESTIGATOR INITIATED STUDY OF THE EFFECTS OF ANDROGEN THERAPY ON CARBOHYDRA
研究人员开始研究雄激素治疗对碳水化合物的影响
  • 批准号:
    7982111
  • 财政年份:
    2008
  • 资助金额:
    $ 1.23万
  • 项目类别:
A PHASE II/III, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL OF URIDINE
尿苷 II/III 期、随机、双盲、安慰剂对照试验
  • 批准号:
    7982124
  • 财政年份:
    2008
  • 资助金额:
    $ 1.23万
  • 项目类别:
HORMONAL REGULATORS OF MUSCLE AND METABOLISM IN AGING (HORMA)--1 R01 AG18169-01
衰老过程中肌肉和新陈代谢的激素调节剂 (HORMA)--1 R01 AG18169-01
  • 批准号:
    7716680
  • 财政年份:
    2008
  • 资助金额:
    $ 1.23万
  • 项目类别:
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