EVALUATION OF HIGH-PROTEIN SUPPLEMENTATION IN WEIGHT-STABLE HIV-POSITIVE

体重稳定的 HIV 阳性患者的高蛋白补充评估

• 批准号: 8168764
• 负责人: FRED R SATTLER
• 金额: $ 1.23万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-10 至 2010-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8168764
• 关键词: Body Weight decreased; CD4 Positive T Lymphocytes; Cells; Computer Retrieval of Information on Scientific Projects Database; Control Groups; Dietary intake; Eating; Energy Intake; Evaluation; Fasting; Funding; Grant; HIV; Institution; Intake; Patients; Proteins; RNA; Randomized; Research; Research Personnel; Resources; Risk; Source; Supplementation; Tissues; Triglycerides; United States National Institutes of Health; Waist-Hip Ratio; Weight; Whey Protein; gastrointestinal symptom; improved; wasting

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. HIV patients with wasting are at increased risk of opportunistic complications and fatality. We hypothesized that augmenting dietary intake with high-biologic-value protein would enhance weight and lean tissue in weight-stable subjects with a prior unintentional weight loss of >3%. Fifty-nine subjects with HIV RNA concentrations <5000 copies/mL were randomly assigned to receive a 280-kcal supplement containing 40 g whey protein or a matched isocaloric control supplement without added protein twice daily for 12 wk. Before the study, intake of total energy and protein exceeded estimated requirements (44.3 ¿ 12.6 kcal/kg/d and 1.69 ¿ 0.55 g/kg/d, respectively). Both supplements failed to increase total energy intake because of decreases in self-selected food intake. Changes in weight (0.8 ¿ 2.4 and 0.7 ¿ 2.4 kg) and lean body mass (0.3 ¿ 1.4 and 0.3 ¿ 1.5 kg) did not differ significantly between the whey protein and control groups, respectively. Waist-to-hip ratio improved more with whey protein (-0.02 ¿ 0.05) than in control (0.01 ¿ 0.03; P=0.025) at week 6 but not at week 12. Fasting triacylglycerol increased by 39 ¿ 98 mg/dL with the control supplement and decreased by 16 ¿ 62 mg/dL with whey protein at week 12 (P=0.03). CD4 lymphocytes increased by 31 ¿ 84 cells/mm3 with whey protein and decreased by 5 ¿ 124 cells/mm3 with the control supplement at 12 wk (P=0.03). Gastrointestinal symptoms occurred more often with whey protein.

该副本是使用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这是调查员的机构。 浪费的艾滋病毒患者有机会性并发症和死亡的风险增加。我们假设使用高生物学价蛋白增强饮食摄入量将增强体重稳定受试者的体重和瘦肉组织，而先前的无意体重损失> 3％。将<5000份/mL的HIV RNA浓度的59名受试者随机分配，以接收含有40 G乳清蛋白或匹配的等量平衡对照补充剂的280千吨补充剂，而无需每天两次添加蛋白质，为12 wk。在研究之前，总能量和蛋白质的摄入量超过估计要求（44.3€12.6 kcal/kg/d和1.69€0.55 g/kg/d）。由于自选择的食物摄入量的下降，两种补充剂都无法增加总能量摄入。体重（0.8€2.4和0.7€2.4 kg）和瘦体重（0.3€1.4和0.3€1.5€1.5 kg）的变化分别在乳清蛋白和对照组之间没有显着。乳清蛋白的腰围比（-0.02€0.05）的进步要高于第6周的对照（0.01€0.03； 0.03; p = 0.025），但在第12周时没有。空腹三酰基甘油含量增加了39�98mg/dl，与对照补充补充补充补充剂，并减少了16 62 mg/dl week week week week week perein per = 0.0 30（p）。 CD4淋巴细胞用乳清蛋白增加了84个细胞/mm3，并在12 WK时用对照补充剂改进了5»124个细胞/mm3（p = 0.03）。乳清蛋白的胃肠道症状更常见。