TESTOSTERONE AND GROWTH HORMONE IMPROVE BODY COMPOSITION AND

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。所列机构为 中心，不一定是研究者的机构。 随着年龄的增长，垂体-性腺轴的损伤与肌肉质量和功能的丧失以及上身脂肪的积累有关。我们测试了一个假设，即生理补充睾酮和生长激素一起改善身体组成和肌肉功能在65-90岁的男性低睾酮和IGF-1水平。这是一项在美国西部、中部和东部的三所大学研究中心进行的析因（2X 3）两层、随机、双盲研究。我们招募了122名70.8 <$4.2岁的社区居住男性，BMI=27.4 <$3.4kg/m2，睾酮d19.1nmol/L（550 ng/dL）和IGF-1处于较低的成人三分位数（d21.9nmol/L= 167 ng/dL）。干预措施包括在用醋酸亮丙瑞林（7.5 mg/月）和生长激素（0、3或5 ug/kg/天）抑制内源性睾酮的同时，经皮给予睾酮（5 g或10 g/天），持续16周。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. With aging, impairments in the pituitary-gonadal axis are associated with loss of muscle mass and function and accumulation of upper body fat. We tested the hypothesis that physiologic supplementation with testosterone and growth hormone together improves body composition and muscle function in 65-90 year-old men with low testosterone and IGF-1 levels. This was a factorial (2X3) two tiered, randomized, double masked investigation conducted at three university research centers located in the western, central and eastern United States. We enrolled 122 community dwelling men 70.8¿4.2 years-of-age with BMI=27.4¿3.4kg/m2, testosterone d19.1nmol/L (550ng/dL) and IGF-1 in lower adult tertile (d21.9nmol/L=167ng/dL). The interventions included transdermal testosterone (5g or 10g/day) during suppression of endogenous testosterone with leuprolide acetate (7.5mg/monthly) and growth hormone (0, 3, or 5ug/kg/day) for 16 weeks.