TESTOSTERONE AND GROWTH HORMONE IMPROVE BODY COMPOSITION AND

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 随着年龄的增长，垂体-性腺轴的损伤与肌肉质量和功能的丧失以及上半身脂肪的积累有关。我们测试了这样一种假设，即在65-90岁的男性中低睾酮和IGF-1水平的人中，同时补充睾酮和生长激素可以改善身体成分和肌肉功能。这是一项析因(2X3)两层随机双掩蔽调查，在美国西部、中部和东部的三个大学研究中心进行。社区男性122例，体重指数为27.4±3.4 kg/m~2，睾酮d19.1nmol/L(550 ng/dL)，胰岛素样生长因子-1(d21.9nmol/L=167 ng/dL)。干预措施包括在醋酸亮丙瑞林(7.5 mg/月)和生长激素(0、3或5ug/kg/d)抑制内源性睾酮的过程中，透皮睾酮(5g或10g/d)，共16周。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. With aging, impairments in the pituitary-gonadal axis are associated with loss of muscle mass and function and accumulation of upper body fat. We tested the hypothesis that physiologic supplementation with testosterone and growth hormone together improves body composition and muscle function in 65-90 year-old men with low testosterone and IGF-1 levels. This was a factorial (2X3) two tiered, randomized, double masked investigation conducted at three university research centers located in the western, central and eastern United States. We enrolled 122 community dwelling men 70.8¿4.2 years-of-age with BMI=27.4¿3.4kg/m2, testosterone d19.1nmol/L (550ng/dL) and IGF-1 in lower adult tertile (d21.9nmol/L=167ng/dL). The interventions included transdermal testosterone (5g or 10g/day) during suppression of endogenous testosterone with leuprolide acetate (7.5mg/monthly) and growth hormone (0, 3, or 5ug/kg/day) for 16 weeks.