TESTOSTERONE AND GROWTH HORMONE IMPROVE BODY COMPOSITION AND

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 随着年龄的增长，垂体-性腺轴的损伤与肌肉质量和功能的丧失以及上半身脂肪的积累有关。我们测试了这样的假设：睾酮和生长激素的生理补充可以改善睾酮和 IGF-1 水平较低的 65-90 岁男性的身体成分和肌肉功能。这是一项阶乘 (2X3) 两层、随机、双盲调查，在位于美国西部、中部和东部的三个大学研究中心进行。我们招募了 122 名年龄为 70.8×4.2 岁的社区居民，BMI=27.4×3.4kg/m2，睾酮 d19.1nmol/L (550ng/dL) 和 IGF-1 处于较低的成人三分位数 (d21.9nmol/L=167ng/dL)。干预措施包括在用醋酸亮丙瑞林（7.5mg/每月）和生长激素（0、3或5ug/kg/天）抑制内源性睾酮期间使用透皮睾酮（5g或10g/天），持续16周。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. With aging, impairments in the pituitary-gonadal axis are associated with loss of muscle mass and function and accumulation of upper body fat. We tested the hypothesis that physiologic supplementation with testosterone and growth hormone together improves body composition and muscle function in 65-90 year-old men with low testosterone and IGF-1 levels. This was a factorial (2X3) two tiered, randomized, double masked investigation conducted at three university research centers located in the western, central and eastern United States. We enrolled 122 community dwelling men 70.8¿4.2 years-of-age with BMI=27.4¿3.4kg/m2, testosterone d19.1nmol/L (550ng/dL) and IGF-1 in lower adult tertile (d21.9nmol/L=167ng/dL). The interventions included transdermal testosterone (5g or 10g/day) during suppression of endogenous testosterone with leuprolide acetate (7.5mg/monthly) and growth hormone (0, 3, or 5ug/kg/day) for 16 weeks.