TESTOSTERONE AND GROWTH HORMONE IMPROVE BODY COMPOSITION AND

睾酮和生长激素改善身体成分

• 批准号: 8361388
• 负责人: FRED R SATTLER
• 金额: $ 1.22万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361388
• 关键词: Adult; Age-Years; Aging; Body Composition; Body fat; Communities; Enrollment; Funding; Grant; Impairment; Insulin-Like Growth Factor I; Intervention; Investigation; Leuprolide Acetate; Masks; Mass Spectrum Analysis; Muscle function; National Center for Research Resources; Physiological; Principal Investigator; Randomized; Research; Research Infrastructure; Resources; Somatotropin; Source; Supplementation; Testing; Testosterone; United States; United States National Institutes of Health; Universities; biomedical resource; cost; improved; men; muscle form; older men; pituitary gonadal axis

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. With aging, impairments in the pituitary-gonadal axis are associated with loss of muscle mass and function and accumulation of upper body fat. We tested the hypothesis that physiologic supplementation with testosterone and growth hormone together improves body composition and muscle function in 65-90 year-old men with low testosterone and IGF-1 levels. This was a factorial (2X3) two tiered, randomized, double masked investigation conducted at three university research centers located in the western, central and eastern United States. We enrolled 122 community dwelling men 70.8¿4.2 years-of-age with BMI=27.4¿3.4kg/m2, testosterone d19.1nmol/L (550ng/dL) and IGF-1 in lower adult tertile (d21.9nmol/L=167ng/dL). The interventions included transdermal testosterone (5g or 10g/day) during suppression of endogenous testosterone with leuprolide acetate (7.5mg/monthly) and growth hormone (0, 3, or 5ug/kg/day) for 16 weeks.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 随着衰老的衰老，垂体基达轴的损伤与肌肉质量以及上身脂肪的功能和积累有关。我们测试了以下假设：在65-90岁的睾丸激素和IGF-1水平的65-90岁男性中，用睾丸激素和生长马共同补充了身体成分和肌肉功能。这是一个阶乘（2x3），在美国西部，中部和东部的三个大学研究中心进行了两个分层，随机，双蒙面的投资。我们招募了122名社区住宅男子70.8？4.2岁，BMI = 27.4？3.4kg/m2，睾丸激素D19.1NMOL/L（550ng/dl）和IGF-1在较低的成人第三位（D21.9nmol/L = 167ng/dl）中。干预措施包括在抑制内源性睾丸激素中用乙酸亮脂蛋白（7.5mg/每月）和生长马烯（0、3或5EG/kg/day）抑制内源性睾丸激素期间的透皮睾丸激素（5G或10G/天）。