TESTOSTERONE AND GROWTH HORMONE IMPROVE BODY COMPOSITION AND

睾酮和生长激素改善身体成分

• 批准号: 8361388
• 负责人: FRED R SATTLER
• 金额: $ 1.22万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361388
• 关键词: Adult; Age-Years; Aging; Body Composition; Body fat; Communities; Enrollment; Funding; Grant; Impairment; Insulin-Like Growth Factor I; Intervention; Investigation; Leuprolide Acetate; Masks; Mass Spectrum Analysis; Muscle function; National Center for Research Resources; Physiological; Principal Investigator; Randomized; Research; Research Infrastructure; Resources; Somatotropin; Source; Supplementation; Testing; Testosterone; United States; United States National Institutes of Health; Universities; biomedical resource; cost; improved; men; muscle form; older men; pituitary gonadal axis

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. With aging, impairments in the pituitary-gonadal axis are associated with loss of muscle mass and function and accumulation of upper body fat. We tested the hypothesis that physiologic supplementation with testosterone and growth hormone together improves body composition and muscle function in 65-90 year-old men with low testosterone and IGF-1 levels. This was a factorial (2X3) two tiered, randomized, double masked investigation conducted at three university research centers located in the western, central and eastern United States. We enrolled 122 community dwelling men 70.8¿4.2 years-of-age with BMI=27.4¿3.4kg/m2, testosterone d19.1nmol/L (550ng/dL) and IGF-1 in lower adult tertile (d21.9nmol/L=167ng/dL). The interventions included transdermal testosterone (5g or 10g/day) during suppression of endogenous testosterone with leuprolide acetate (7.5mg/monthly) and growth hormone (0, 3, or 5ug/kg/day) for 16 weeks.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 子项目的主要研究者可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 随着年龄的增长，垂体-性腺轴的损伤与肌肉质量和功能的丧失以及上身脂肪的积累有关。我们测试了一个假设，即生理补充睾酮和生长激素一起改善身体组成和肌肉功能在65-90岁的男性低睾酮和IGF-1水平。这是一项在美国西部、中部和东部的三所大学研究中心进行的析因（2X 3）两层、随机、双盲研究。我们招募了122名70.8 <$4.2岁的社区居住男性，BMI=27.4 <$3.4kg/m2，睾酮d19.1nmol/L（550 ng/dL）和IGF-1处于较低的成人三分位数（d21.9nmol/L= 167 ng/dL）。干预措施包括在用醋酸亮丙瑞林（7.5 mg/月）和生长激素（0、3或5 ug/kg/天）抑制内源性睾酮的同时，经皮给予睾酮（5 g或10 g/天），持续16周。