CYSTEINE TARGETED REDOX REGULATION OF PROTEINS HOW WIDESPREAD IS REGULATION BY SULPHINIC ACID FORMATION?

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Ischaemic heart disease is the most common cause of mortality in the Western world and accounts for more than 150,000 deaths per year in the U.K. When blood flow to a region of the heart is reduced by narrowing or blocking of a coronary artery (ischaemia), the heart muscle becomes injured and, if the blockage is severe, the heart muscle will die (infarct). This is essentially what happens during a heart attack. It is essential therefore that the flow in the blocked coronary artery is rapidly restored (reperfusion) if the heart muscle is to survive. During ischaemia and reperfusion toxic forms of oxygen (free radicals) are produced that damage crucial components of the cell, including proteins. We have developed several new methods that allow us to identify heart proteins that are oxidised by free radicals during ischaemia and reperfusion. The identification of these proteins will help us understand the mechanisms of injury during ischaemia and reperfusion and identify possible therapeutic strategies to combat injury during a heart attack.