Thiol-disulfide redox switches in protein kinases and their role in cardiovascular health and disease

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Whilst oxidants may contribute to the pathogenesis of cardiovascular disease, many of them also function as important signalling molecules, carrying vital information about cellular redox state. Oxidants are crucial for adaptation of the cardiovascular system during health, as well as during disease. Oxidants can regulate biological processes by inducing structural modifications of proteins, which can changes their function. This application seeks funds to capitalise on our recent identification of new redox sensors. Our aim is to define the role of these newly identified redox sensors proteins in cardiovascular health and disease. These studies may provide new insight to targets for drug development that improve human health in the setting cardiovascular disease. This is important as cardiovascular disease is the leading cause of death in the world, including in the United Kingdom.