Identifying genetic and environmental factors that cause NAD deficiency and disrupt embryogenesis

识别导致 NAD 缺乏和破坏胚胎发生的遗传和环境因素

• 批准号: nhmrc : GNT1162878
• 金额: $ 189.35万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/identifying-genetic-environmental-disrupt-embryogenesis/1379261
• 关键词: Identifying; genetic; environmental; factors; cause

In humans, some 30% of pregnancies are lost before term and 3-6% of babies are born with malformation. These birth defects are a leading cause of infant mortality and are more prevalent than most chronic diseases of childhood. Recently we discovered an important cause of complex birth defects where the affected individuals had cardiac, vertebral and renal defects, among others. We are conducting research in mice to determine if our findings are likely to apply to the wider community.

在人类中，约 30% 的妊娠在足月前流产，3-6% 的婴儿出生时存在畸形。这些出生缺陷是婴儿死亡的主要原因，并且比大多数儿童期慢性疾病更为普遍。最近，我们发现了复杂出生缺陷的一个重要原因，其中受影响的个体患有心脏、椎骨和肾脏缺陷等。我们正在对小鼠进行研究，以确定我们的研究结果是否可能适用于更广泛的社区。