Identifying genetic and environmental factors that cause NAD deficiency and disrupt embryogenesis

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In humans, some 30% of pregnancies are lost before term and 3-6% of babies are born with malformation. These birth defects are a leading cause of infant mortality and are more prevalent than most chronic diseases of childhood. Recently we discovered an important cause of complex birth defects where the affected individuals had cardiac, vertebral and renal defects, among others. We are conducting research in mice to determine if our findings are likely to apply to the wider community.