Identifying the mechanism and spectrum of activity of the antiviral protein IFITM3

为了应对感染，体内的细胞能够表达一系列帮助它们抵抗感染的分子，其中一种分子是干扰素诱导的跨膜蛋白3 （IFITM3）。这种最近发现但研究不足的强效抗病毒蛋白显著影响小鼠和人类的流感感染过程。我们将探索IFITM3抗病毒活性的机制，并确定启动和保持表达的重要因素。

In response to an infection cells within the body are capable of expressing a range of molecules that help them resist infection, one such molecule is interferon induced transmembrane protein 3 (IFITM3). This recently identified but poorly studied potent antiviral protein dramatically influences the course of influenza infection in both mice and humans. We will explore the mechanisms of antiviral activity of IFITM3 and determine factors important in initiating and retaining expression.