IFITM3 - making cells resistant to virus infection

IFITM3 - 使细胞抵抗病毒感染

• 批准号: nhmrc : GNT1059051
• 负责人: Dr Linda Wakim
• 金额: $ 32.71万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/ifitm3-making-cells-virus-infection/1344670
• 关键词: IFITM3; making; cells; resistant; virus

In response to an infection cells within the body are capable of expressing a range of molecules that help them resist infection, one such molecule is interferon induced transmembrane protein 3 (IFITM3). This recently identified but poorly studied potent antiviral protein dramatically influences the course of influenza infection in both mice and humans. We will explore the mechanisms of antiviral activity of IFITM3 and determine factors important in initiating and retaining expression.

为了应对感染，体内的细胞能够表达一系列帮助它们抵抗感染的分子，其中一个分子是干扰素诱导的跨膜蛋白3(IFITM3)。这种最近发现但研究很少的有效抗病毒蛋白极大地影响了小鼠和人类的流感感染过程。我们将探索IFITM3的抗病毒活性的机制，并确定启动和保持表达的重要因素。