Long lived, virus resistant resident memory T cells

将记忆T细胞存款在肺、肠道和生殖道内的疫苗具有巨大的治疗潜力，因为这些粘膜表面是许多病毒进入体内的主要门户。然而，粘膜组织内大量T细胞的积累可能会增加T细胞营养型病毒（如HIV）感染的靶细胞数量。我们将探索在产生粘膜记忆T细胞中重要的因素，这些细胞也能抵抗病毒感染。

Vaccines that deposit memory T cells within the lung, gut and genital tract hold enormous therapeutic potential, as these mucosal surfaces are major portals of entry into the body for many viruses. However, the accumulation of large numbers of T cells within the mucosal tissue may increase the number of target cells for T cell trophic viruses (eg HIV) to infect. We will explore factors that are important in the generation of mucosal memory T cells that are also resistant to virus infection.