Virus resistant mucosal resident memory T cells

抗病毒粘膜常驻记忆T细胞

• 批准号: nhmrc : 1042530
• 负责人: Dr Linda Wakim
• 金额: $ 39.62万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/virus-resistant-mucosal-t-cells/111482
• 关键词: Virus; resistant; mucosal; resident; memory

Vaccines that deposit memory T cells within the lung, gut and genital tract hold enormous therapeutic potential, as these mucosal surfaces are major portals of entry into the body for many viruses. However, the accumulation of large numbers of T cells within the mucosal tissue may increase the number of target cells for T cell trophic viruses (eg HIV) to infect. We will explore factors that result in the generation of mucosal memory T cells that are resistant to virus infection.

将记忆T细胞存款在肺、肠道和生殖道内的疫苗具有巨大的治疗潜力，因为这些粘膜表面是许多病毒进入体内的主要门户。然而，粘膜组织内大量T细胞的积累可能会增加T细胞营养型病毒（如HIV）感染的靶细胞数量。我们将探讨导致产生对病毒感染有抵抗力的粘膜记忆T细胞的因素。