Virus resistant mucosal resident memory T cells

在肺、肠道和生殖道内储存记忆T细胞的疫苗具有巨大的治疗潜力，因为这些粘膜表面是许多病毒进入人体的主要门户。然而，粘膜组织内大量T细胞的积累可能会增加T细胞营养病毒（如HIV）感染的靶细胞数量。我们将探索导致产生抵抗病毒感染的粘膜记忆T细胞的因素。

Vaccines that deposit memory T cells within the lung, gut and genital tract hold enormous therapeutic potential, as these mucosal surfaces are major portals of entry into the body for many viruses. However, the accumulation of large numbers of T cells within the mucosal tissue may increase the number of target cells for T cell trophic viruses (eg HIV) to infect. We will explore factors that result in the generation of mucosal memory T cells that are resistant to virus infection.