An exploration of the balance between West Nile Virus pathogenesis and immune system mediated control

西尼罗河病毒发病机制与免疫系统介导控制之间平衡的探索

• 批准号: nhmrc : 567011
• 负责人: Dr Linda Wakim
• 金额: $ 21.7万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/an-exploration-balance-mediated-control/116023
• 关键词: exploration; balance; between; West; Nile

West Nile Virus (WNV) is a mosquito transmitted infectious disease that is emerging globally. Infection can lead to the development of fatal encephalitis and currently there is no vaccine available for human use. Killer T cells, a component of the immune system, are essential for viral clearance from the brain. This project aims to further explore WNV pathogenesis and whether killer T cells can be utilized to keep the infection localised and prevent the spread of the virus to the brain.

西尼罗河病毒（WNV）是一种蚊子传播的传染病，正在全球范围内出现。感染可导致致命性脑炎的发展，目前还没有可供人类使用的疫苗。杀伤性T细胞是免疫系统的一个组成部分，对于从大脑中清除病毒至关重要。该项目旨在进一步探索西尼罗河病毒的发病机制，以及是否可以利用杀伤性T细胞来保持感染局部化并防止病毒传播到大脑。