Biology of Infectious Diseases Training Program

描述(由申请人提供)：这是加州大学旧金山分校传染病生物学培训计划的第二次修订后的竞争续签申请，旨在培训医生和科学家在传染病的基础科学研究方面从事富有成效的职业生涯。传染病是美国第三大常见死亡原因，尽管抗生素、疫苗和高标准的公共卫生得到了广泛的应用。在世界范围内，传染病是主要的死亡原因。新病原体的出现、旧病原体的重新出现、抗菌剂耐药性的增加以及全球化的压力打破了障碍，助长了传染病的传播。控制和控制传染病传播的战略将越来越依赖于强有力的流行病学和以人群为基础的方法以及基础研究方面的进展，这些方法和进展是由于基因组学、微生物发病机制和免疫学领域的发现的应用而产生的。加州大学旧金山分校的传染病生物学培训计划是根据美国传染病学会的指南和建议建立的，有两个培训轨道，一个是基础研究人员轨道，一个是临床研究人员轨道。这两个轨道为获取和转化研究工具、技能和经验以及培养科学创造力提供了结构框架，而科学创造力是成功的以研究为导向的职业所必需的。这种双轨结构也为跨学科交流和互动提供了机会。该项目得益于完善的教学基础设施和互动教员，他们指导研究项目，提供丰富和多样化的培训环境，具有非凡的深度和质量。培训的重点是MD和MD-PhD申请者，但也接受博士后候选人。该计划只存在了五年，在将受训人员过渡到独立的研究资金来源并开始他们有前途的职业轨迹方面取得了相当大的成功。这份修订后的申请采用了一项创新计划，招募代表人数不足的少数族裔学员加入该计划；我们认为，作为前一版本的弱点，这一计划代表了修订后的计划的一大优势。相关性：拟议的培训计划与公共卫生高度相关，其中一个主要问题是传染病的控制。我们将培训下一代负责公共卫生的医学科学家，并制定战略，以遏制传染病病原体构成的威胁；科学家将进行必要的研究，以确定新的病原体；以及那些将发现克服它们的方法和疗法的科学家。

DESCRIPTION (provided by applicant): This is a second revised application for competitive renewal for the UCSF Biology of Infectious Diseases Training Program to train physician-scientists for productive careers in fundamental scientific investigations of infectious diseases. Infectious diseases are the third most common cause of death in the United States, despite widespread availability of antibiotics, vaccines, and high standards of public health. Worldwide, infectious diseases are the leading cause of death. Emergence of new pathogens, re-emergence of old ones, increasing resistance to antimicrobials, and pressures of globalization have broken down barriers and contributed to the spread of infectious diseases. Strategies to contain and control the spread of infectious diseases increasingly will rely on strong epidemiologic and population-based approaches and advances in basic research resulting from applications of discoveries in the fields of genomics, microbial pathogenesis, and immunology. The UCSF Biology of Infectious Diseases Training Program, which is modeled according to Infectious Diseases Society of America guidelines and recommendations, features two training tracks, a Basic Investigator Track and a Clinical Investigator Track. These two tracks provide the structural framework for acquisition and translation of research tools, skills, and experiences and for cultivating the scientific creativity that are essential for a successful research-oriented career. The two-track structure also affords the opportunity for interdisciplinary exchange and interactions. The program benefits from a well-established didactic infrastructure and an interactive faculty who direct research programs offering a rich and diversified training environment of exceptional depth and quality. Training is focused on MD and MD-PhD applicants, but PhD post-doctoral candidates are also accepted. In existence for only five years, the program has had considerable success in transitioning trainees to independent sources of research funding and starting them on promising career trajectories. This revised application features an innovative plan to recruit underrepresented minority trainees into the program; viewed as the weakness of the previous version, we believe this plan represents a major strength of the revised proposal. Relevance: The proposed training program is highly relevant to public health, a major concern of which is the control of infectious diseases. We will be training the next generation of medical scientists who will have responsibility for public health and devising strategies to contain the threats posed by infectious agents, scientists who will conduct the studies needed to identify new agents, and those who will discover approaches and therapies to overcome them.